(E)-(4-[3-Oxo-3-(1-(3,4-methylenedioxyphenyl)-1,3,4,9-tetrahydro-β-carbolin-2-yl)propenyl]benzyloxy)acetic acid | 199676-36-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: (E)-(4-[3-Oxo-3-(1-(3,4-methylenedioxyphenyl)-1,3,4,9-tetrahydro-β-carbolin-2-yl)propenyl]benzyloxy)acetic acid
• 英文别名: (E)-(4-[3-Oxo-3-(1-(3,4-methylenedioxyphenyl)-1,3,4,9-tetrahydro-beta-carbolin-2-yl)propenyl]-benzyloxy)acetic acid；2-[[4-[(E)-3-[1-(1,3-benzodioxol-5-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-3-oxoprop-1-enyl]phenyl]methoxy]acetic acid
• CAS: 199676-36-3
• 化学式: C₃₀H₂₆N₂O₆
• 分子量: 510.546
• InChiKey: YODLDAVVLOSHFB-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (E)-(4-[3-oxo-3-(1-(3,4-methylenedioxyphenyl)-1,3,4,9-tetrahydro-β-carbolin-2-yl)propenyl]benzyloxy)acetic acid, ethyl ester 以 乙醇 为溶剂， 以40%的产率得到(E)-(4-[3-Oxo-3-(1-(3,4-methylenedioxyphenyl)-1,3,4,9-tetrahydro-β-carbolin-2-yl)propenyl]benzyloxy)acetic acid
  参考文献：
  名称：

  Carboline derivatives

  摘要：

  化合物(I)的碳胺酸衍生物是环鸟苷3',5'-单磷酸特异性磷酸二酯酶（cGMP特异性PDE）的有效且选择性抑制剂，并在多种治疗领域具有用途，包括心血管疾病和勃起功能障碍的治疗。

  公开号：

  US06043252A1

文献信息

• Methods for prevention and treatment of gastrointestinal disorders
  申请人：——

  公开号：US20020128171A1

  公开（公告）日：2002-09-12

  Disclosed are methods for preventing or treating a gastrointestinal (GI) disorder in a mammal such as a human patient. In one embodiment, the methods include administering to the mammal a therapeutically effective amount of a compound that modulates a nitric oxide (NO) signaling pathway, particularly in GI neurons. Methods of the invention are particularly useful for the treatment (including prophylactic treatment) of diabetic gastropathies and other GI disorders.

  本发明涉及一种预防或治疗哺乳动物（例如人类患者）胃肠道（GI）疾病的方法。在一种实施例中，该方法包括向哺乳动物（特别是GI神经元）中投与治疗效果的化合物，该化合物调节一氧化氮（NO）信号通路的数量。本发明的方法对于治疗（包括预防性治疗）糖尿病性胃病和其他GI疾病特别有用。
• Pyrrolidine derivatives as prostaglandin modulators
  申请人：Liao Yihua

  公开号：US20050176800A1

  公开（公告）日：2005-08-11

  Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.

  本发明提供了替代吡咯烷化合物，并提供了利用或包含一种或多种这样的化合物的治疗方法和制药组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产、痛经、哮喘、高血压、不孕症或生育障碍、不良血凝、先兆子痫或子痫前期、嗜酸性粒细胞异常、性功能障碍、骨质疏松和其他破坏性骨疾病或疾病，以及与前列腺素家族化合物相关的其他疾病和疾病。在优选方面，替代吡咯烷化合物与磷酸二酯酶抑制剂化合物协同给予病人。
• N-cinnamoyl derivatives of beta-carboline
  申请人：ICOS Corporation

  公开号：US06306870B1

  公开（公告）日：2001-10-23

  Carboline derivatives of formula (I), are potent and selective inhibitors of cyclic guanosine 3′,5′-monophoshate specific phosphodiesterase (cGMP specific PDE) and have utility in a variety of therapeutic areas where such inhibition is thought to be beneficial, including the treatment of cardivascular disorders.

  公式（I）的碳酸盐衍生物是环鸟苷3'，5'-环磷酸特异性磷酸二酯酶（cGMP特异性PDE）的有效和选择性抑制剂，并在许多治疗领域中具有实用性，其中认为这种抑制有益，包括治疗心血管疾病。
• N-cinnamoyl derivatives of (.beta.) carbolines
  申请人：Icos Corporation

  公开号：US06117881A1

  公开（公告）日：2000-09-12

  Carboline derivatives of formula (I), are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP specific PDE) and have utility in a variety of therapeutic areas where such inhibition is thought to be beneficial, including the treatment of cardiovascular disorders. ##STR1##

  公式（I）的碳酸衍生物是环鸟苷酸3'，5'-单磷酸特异性磷酸二酯酶（cGMP特异性PDE）的有效和选择性抑制剂，在许多治疗领域中具有实用价值，包括心血管疾病的治疗。
• PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS
  申请人：LIAO Yihua

  公开号：US20080114051A1

  公开（公告）日：2008-05-15

  Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.

  本发明提供了取代吡咯烷化合物，以及利用或包含一种或多种这样的化合物的治疗方法和制药组合物。本发明的化合物可用于各种疗法，包括治疗或预防早产、痛经、哮喘、高血压、不孕症或生育障碍、不良血凝、妊娠高血压综合症或子痫前期、嗜酸性粒细胞异常、性功能障碍、骨质疏松症和其他破坏性骨疾病或障碍，以及与前列腺素家族化合物相关的其他疾病和障碍。在首选方面，取代吡咯烷化合物与磷酸二酯酶抑制剂化合物协同给予给受试者。