1-(dimethylamino)-1-methyl-2-tetralone | 96866-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-(dimethylamino)-1-methyl-2-tetralone
• 英文别名: 1-(Dimethylamino)-1-methyl-3,4-dihydronaphthalen-2-one
• CAS: 96866-49-8
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: PFKHZAFZGZCHEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(dimethylamino)-2-hydroxy-1-methyl-1,2,3,4-tetrahydronaphthalene 在 jones reagent 作用下， 以 丙酮 为溶剂， 以52%的产率得到1-(dimethylamino)-1-methyl-2-tetralone
  参考文献：
  名称：

  Aminotetralone analogs of ketamine: synthesis and evaluation of hypnotic and locomotor properties in mice

  摘要：

  Ketamine and phencyclidine are structurally similar compounds that share many pharmacological actions, some of which are similar to the phenethylamines amphetamine and cathione. In order to integrate structural features of ketamine and cathinone, two groups of analogues, which are more conformationally restricted compared to the parent compounds, were synthesized for biological evaluation. These included 1-amino-1-methyl-2-tetralone and 2-amino-2-methyl-1-tetralone was well as several N-substituted derivatives of these molecules. Locomotor activity testing in mice revealed that 2-amino-2-methyl-1-tetralone caused an increase in locomotor activity while 1-amino-1-methyl-2-tetralone depressed spontaneous locomotor activity. None of the compounds produced hypnosis or profound ataxia.

  DOI：

  10.1021/jm00147a044

文献信息

• YANG, D. J.;DAVISSON, J. N., J. MED. CHEM., 1985, 28, N 9, 1361-1365
  作者：YANG, D. J.、DAVISSON, J. N.

  DOI：——

  日期：——