1-Methyl-2-(4-methylphenyl)piperazine | 941712-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-Methyl-2-(4-methylphenyl)piperazine
• CAS: 941712-24-9
• 化学式: C₁₂H₁₈N₂
• mdl: MFCD10034697
• 分子量: 190.28
• InChiKey: HJDBFRKZDPXOPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methyl-2-(4-methylphenyl)piperazine 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 N-(1-(2-(4-methyl-3-(p-tolyl)piperazin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide
  参考文献：
  名称：

  CYCLIC PYRAZOLE DIAMIDE IRE1/XBP1S ACTIVATORS

  摘要：

  Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.

  公开号：

  WO2024118810A1
• 作为产物：
  描述：

  Boc-Gly-DL-N(Me)Phg(4-Me)-NHtBu 在 lithium aluminium tetrahydride 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 16.5h， 生成 1-Methyl-2-(4-methylphenyl)piperazine
  参考文献：
  名称：

  CYCLIC PYRAZOLE DIAMIDE IRE1/XBP1S ACTIVATORS

  摘要：

  Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.

  公开号：

  WO2024118810A1

文献信息

• Compounds, compositions, and methods
  申请人：——

  公开号：US20040048853A1

  公开（公告）日：2004-03-11

  Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed.

  本发明公开了用于治疗细胞增殖性疾病和疾病的化合物、组合物和方法，例如，通过调节KSP的活性来实现。
• COMPOUNDS, COMPOSITIONS, AND METHODS
  申请人：Cytokinetics, Inc.

  公开号：EP1539180A2

  公开（公告）日：2005-06-15
• EP1539180A4
  申请人：——

  公开号：EP1539180A4

  公开（公告）日：2006-08-30
• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES
  申请人：CYTOKINETICS INC

  公开号：WO2004018058A2

  公开（公告）日：2004-03-04

  Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed.
• CYCLIC PYRAZOLE DIAMIDE IRE1/XBP1S ACTIVATORS
  申请人：[en]PROTEGO BIOPHARMA, INC.

  公开号：WO2024118810A1

  公开（公告）日：2024-06-06

  Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.