cordysinin C | 110282-66-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: cordysinin C
• 英文别名: 1-(9H-β-carbolin-1-yl)ethanol；cordysinin D；(1S)-1-(9H-pyrido[3,4-b]indol-1-yl)ethanol
• CAS: 110282-66-1
• 化学式: C₁₃H₁₂N₂O
• 分子量: 212.251
• InChiKey: GKXWQOGSNJJLKJ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cordysinin C 、 (R)-methoxytrifluoromethylphenylacetyl chloride 在 吡啶 作用下， 以 氯仿 为溶剂， 生成
  参考文献：
  名称：

  Anti-inflammatory Principles from Cordyceps sinensis

  摘要：

  In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-beta-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.45 +/- 0.15 and 1.68 +/- 0.32 mu M, respectively.

  DOI：

  10.1021/np100902f

文献信息

• Anti-inflammatory Principles from <i>Cordyceps sinensis</i>
  作者：Mei-Lin Yang、Ping-Chung Kuo、Tsong-Long Hwang、Tian-Shung Wu

  DOI：10.1021/np100902f

  日期：2011.9.23

  In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-beta-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.45 +/- 0.15 and 1.68 +/- 0.32 mu M, respectively.