3,7-Dimethyl-6-oxy-1,2,3,6-tetrahydropurin | 19143-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3,7-Dimethyl-6-oxy-1,2,3,6-tetrahydropurin
• 英文别名: 3,7-dimethyl-1,2,3,7-tetrahydro-purin-6-one；3,7-Dimethyl-6-oxy-2,3-dihydropurine；3,7-dimethyl-1,2-dihydropurin-6-one
• CAS: 19143-60-3
• 化学式: C₇H₁₀N₄O
• 分子量: 166.183
• InChiKey: KUZCPNCETGJEJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• HYDROXYL PURINE COMPOUNDS AND USE THEREOF
  申请人：GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD

  公开号：EP3299371A1

  公开（公告）日：2018-03-28

  Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.

  公开了一系列羟基嘌呤化合物及其作为 PDE2 或 TNFα 抑制剂的用途，特别是如式 (I) 所示的化合物或其同系物或其药学上可接受的盐。
• [EN] TUMOR TARGETING CONJUGATES AND METHODS OF USE THEREOF<br/>[FR] CONJUGUÉS CIBLANT LES TUMEURS ET LEURS MÉTHODES D'UTILISATION
  申请人：SILVERBACK THERAPEUTICS INC

  公开号：WO2018140831A2

  公开（公告）日：2018-08-02

  Various compositions are disclosed. The compositions of conjugates comprising immune-stimulatory compounds are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer.