4,5-二溴-2-噻吩羰酰氯 | 21815-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 中文名称: 4,5-二溴-2-噻吩羰酰氯
• 英文名称: 4,5-dibromo-2-thiophenecarboxylic acid chloride
• 英文别名: 2,3-dibromothiophene-5-carboxylic acid chloride；4,5-dibromo-thiophene-2-carbonyl chloride；4,5-dibromo-2-thiophenecarbonyl chloride；4,5-Dibrom-thiophen-2-carbonylchlorid；4.5-dibromothiophene-2-carboxylic chloride；4,5-dibromothiophene-2-carbonyl chloride
• CAS: 21815-07-6
• 化学式: C₅HBr₂ClOS
• 分子量: 304.389
• InChiKey: GHTYWAJRIXJGMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5-二溴-2-噻吩羰酰氯 在 sodium carbonate 、 一水合肼 作用下， 以 四氢呋喃 、 水 为溶剂， 以97%的产率得到4,5-dibromo-2-thiophenecarboxylic acid 2-(4,5-dibromo-2-thienylcarbonyl)hydrazide
  参考文献：
  名称：

  间隔基扩展的Bis-Ene-Yne化合物：范围，局限性和属性

  摘要：

  噻吩对双烯炔化合物的裂解反应已得到系统地研究。这些多功能积木的便捷可及性为功能性有机材料中的新颖应用铺平了道路。

  DOI：

  10.1002/ejoc.201800446
• 作为产物：
  描述：

  4,5-二溴噻吩-2-甲酸 在 氯化亚砜 作用下， 以100%的产率得到4,5-二溴-2-噻吩羰酰氯
  参考文献：
  名称：

  间隔基扩展的Bis-Ene-Yne化合物：范围，局限性和属性

  摘要：

  噻吩对双烯炔化合物的裂解反应已得到系统地研究。这些多功能积木的便捷可及性为功能性有机材料中的新颖应用铺平了道路。

  DOI：

  10.1002/ejoc.201800446

文献信息

• Microbicidal compositions based on dibromo-thiophene-carboxylic acid
  申请人：Bayer Aktiengesellschaft

  公开号：US05789437A1

  公开（公告）日：1998-08-04

  New microbicidal compositions based on dibromo-thiophene-carboxylic acid derivatives which are known in some cases, of the formula ##STR1## in which R represents the groups --XR.sup.1, --NR.sup.2 R.sup.3, --NR.sup.4 OR.sup.5 or --NR.sup.4 --N(R.sup.5).sub.2, where X represents oxygen or sulphur and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings indicated in the description, and the use of these substances for controlling undesired microorganisms. New dibromo-thiophene-carboxylic acid derivatives of the formula ##STR2## in which R.sup.9 represents the groups --SR.sup.1, --OR.sup.10, ##STR3## in which R.sup.1, R.sup.4, R.sup.5, R.sup.10, R.sup.11, R.sup.12 and R.sup.13 have the meaning indicated in the description, and processes for the preparation of the substances of the formula (I-A).

  基于已知的一些情况下的二溴噻吩羧酸衍生物的新微生物杀灭组合物，其化学式为##STR1##其中R代表基团--XR.sup.1，--NR.sup.2 R.sup.3，--NR.sup.4 OR.sup.5或--NR.sup.4 --N(R.sup.5).sub.2，其中X代表氧或硫，R.sup.1，R.sup.2，R.sup.3，R.sup.4和R.sup.5具有描述中指示的含义，并且利用这些物质来控制不受欢迎的微生物。化学式为##STR2##其中R.sup.9代表基团--SR.sup.1，--OR.sup.10，##STR3##其中R.sup.1，R.sup.4，R.sup.5，R.sup.10，R.sup.11，R.sup.12和R.sup.13具有描述中指示的含义，并且用于制备化合物(I-A)的方法。
• Thiophene-2-carboxylic acid derivatives, their preparation and their use
  申请人：BASF Aktiengesellschaft

  公开号：US05034049A1

  公开（公告）日：1991-07-23

  Thiophene-2-carboxylic acid derivatives of the general formula I ##STR1## where R.sup.1 to R.sup.3 are each hydrogen, halogen, branched or straight-chain C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.8 -alkoxy, C.sub.1 -C.sub.6 -haloalkyl, C.sub.1 -C.sub.6 -haloalkoxy, nitro, cyano, unsubstituted phenyl or phenyl which is mono- to trisubstituted by C.sub.1 -C.sub.4 -alkyl, halogen, C.sub.1 -C.sub.5 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.5 -haloalkoxy; X is --OR.sup.4 or --NH--OR.sup.5, R.sup.4 being branched or straight-chain C.sub.3 -C.sub.10 -alkynylalkyl which is unsubstituted or substituted by halogen; and R.sup.5 being branched or straight-chain C.sub.1 -C.sub.5 -alkyl which is unsubstituted or substituted by halogen, or branched or straight-chain C.sub.3 -C.sub.10 -alkynylalkyl which is unsubstituted or substituted by halogen; with the proviso that R.sup.4 is not propargyl when R.sup.2 and R.sup.3 are both hydrogen or when R.sup.2 is halogen or R.sup.3 is chlorine, methyl or methoxy. The compounds I are suitable for combating the growth of unwanted plants.

  通式I的噻吩-2-羧酸衍生物##STR1##其中R.sup.1至R.sup.3分别是氢、卤素、支链或直链C.sub.1-C.sub.6-烷基、C.sub.1-C.sub.8-烷氧基、C.sub.1-C.sub.6-卤代烷基、C.sub.1-C.sub.6-卤代烷氧基、硝基、氰基、未取代苯基或经C.sub.1-C.sub.4-烷基、卤素、C.sub.1-C.sub.5-卤代烷基、C.sub.1-C.sub.4-烷氧基或C.sub.1-C.sub.5-卤代烷氧基单取代至三取代的苯基; X为--OR.sup.4或--NH--OR.sup.5，其中R.sup.4为支链或直链C.sub.3-C.sub.10-炔基烷基，未取代或经卤素取代; R.sup.5为支链或直链C.sub.1-C.sub.5-烷基，未取代或经卤素取代，或支链或直链C.sub.3-C.sub.10-炔基烷基，未取代或经卤素取代; 但R.sup.4不为丙炔基当R.sup.2和R.sup.3都是氢或当R.sup.2是卤素或R.sup.3是氯、甲基或甲氧基时。化合物I适用于防治不受欢迎植物的生长。
• Compounds with antifungal properties and process thereof
  申请人：Gurjar Mukund Keshav

  公开号：US20070259948A1

  公开（公告）日：2007-11-08

  The present invention relates to compounds of formula (1), its solvates and pharmaceutically acceptable salts having antifungal activity and its pharmaceutical composition comprising an effective amount of compound of formula (1) wherein R is substituted alkyl, alkenyl, aryl, heteroaryl, 2-thienyl, 3-thienyl, halothienyl, haloalkyl, halophenyl, or pyrrolyl; and R 1 and R 2 , each independent of the other, are hydrogen, halogen, or alkoxy. The invention also relates to a process for the preparation of said compounds by contacting the intermediate alcohol, prepared from 1,2-O-isopropylideneglyceraldehyde and substituted phenylacetates, with acid chlorides under appropriate conditions to obtain some of the preferred compounds of the invention.

  本发明涉及具有抗真菌活性的化合物的化学式（1），其溶剂合物和药学上可接受的盐，以及包括化学式（1）化合物的有效量的药物组合物，其中R为取代烷基，烯基，芳基，杂芳基，2-噻吩基，3-噻吩基，卤代噻吩基，卤代烷基，卤代苯基或吡咯基；R1和R2，彼此独立，分别为氢，卤素或烷氧基。该发明还涉及一种制备所述化合物的方法，通过将从1,2-O-异丙基亚甲基二羟基丙醛和取代苯乙酸酯制备的中间醇与酸氯化物在适当条件下接触以获得本发明的一些首选化合物。
• Process for making 3-aroyl-2-oxindole-1-carboxamides
  申请人：Pfizer Inc.

  公开号：US05059693A1

  公开（公告）日：1991-10-22

  Process for making antiinflammatory 3-aroyl-2-oxindole-1-carboxamides by reductive debromination or deiodination of 3-(bromo- or iodoaroyl)-2-oxindole-1-carboxamides.

  制备抗炎症3-芳酰基-2-氧喹啉-1-羧酰胺的过程是通过对3-(溴或碘芳酰基)-2-氧喹啉-1-羧酰胺进行还原去溴或去碘。
• Substituted thiophenecarboxamides
  申请人：Bayer Aktiengesellschaft

  公开号：US05369124A1

  公开（公告）日：1994-11-29

  Novel substituted thiophenecarboxamides of the formula (I), ##STR1## in which R represents hydrogen or alkyl, A represents doubly linked alkanediyl, Ar represents optionally substituted aryl and n represents a number 0 or 1, with the exception of the compounds 4,5-dibromo-thiophene-2-carboxylic acid N-(4-bromophenyl)-amide, 4,5-dibromo-thiophene-2-carboxylic acid N-(2,3-dichlorophenyl)-amide and 4,5-dibromo-thiophene-2-carboxylic acid N-[2-(3,4-dimethoxyphenyl)-ethyl]-amide, and their use for combating pests. The novel compounds are described by the formula (I) and they can be prepared by analogous processes, e.g. by reacting suitable thiophenecarbonyl halides with suitable amines.

  化合物的名称为Novel substituted thiophenecarboxamides，化学式为(I)：##STR1## 其中，R代表氢或烷基，A代表双键连接的烷基，Ar代表可选取代的芳基，n代表数字0或1。除了化合物4,5-二溴噻吩-2-羧酸N-(4-溴苯基)-酰胺、4,5-二溴噻吩-2-羧酸N-(2,3-二氯苯基)-酰胺和4,5-二溴噻吩-2-羧酸N-[2-(3,4-二甲氧基苯基)-乙基]-酰胺外，这些新化合物可用于防治害虫。化合物的制备方法可以通过类似的过程进行，例如通过反应适当的噻吩羧酰卤与适当的胺反应来制备。