4-Cyano-2-propylimidazo[4,5-c]pyridine | 136646-83-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 4-Cyano-2-propylimidazo[4,5-c]pyridine
• 英文别名: 2-propyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile
• CAS: 136646-83-8
• 化学式: C₁₀H₁₀N₄
• 分子量: 186.216
• InChiKey: FSZHDICPELRRSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  65.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Fused imidazole derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0434038A1

  公开（公告）日：1991-06-26

  Novel fused imidazole derivatives of the formula (I): wherein the ring A, which may be optionally substituted, is a six-membered heteroaromatic group having one or two hetero nitrogen atoms; R¹ is hydrogen or an alkyl, aralkyl or aryl group which may be optionally substituted; R² is hydrogen, halogen or nitro; R³ is a residue capable of forming an anion or a residue convertible into an anion; X is a direct bond or a spacer-having atomic length of two or less; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof have potent angiotensin II antagonist activity and hypotensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.

  新型融合的咪唑衍生物的化学式（I）：其中，环A是一个可能被取代的六元杂芳基团，具有一个或两个杂原子；R¹是氢或一个可以选择性取代的烷基、芳基或芳基烷基；R²是氢、卤素或硝基；R³是能够形成负离子的残基或可转化为负离子的残基；X是直接键或具有原子长度为两个或更少的间隔子；n是1或2的整数；其药学上可接受的盐具有强大的抗血管紧张素II活性和降压活性，因此可用作治疗循环系统疾病如高血压疾病、心脏疾病、中风等的治疗剂。