[2-(Hexadecylamino)-1-phosphonoethyl]phosphonic acid | 1303493-43-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: [2-(Hexadecylamino)-1-phosphonoethyl]phosphonic acid
• CAS: 1303493-43-7
• 化学式: C₁₈H₄₁NO₆P₂
• 分子量: 429.474
• InChiKey: COQXHRWQBQYKCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 [2-(Hexadecylamino)-1-phosphonoethyl]phosphonic acid
  参考文献：
  名称：

  抗克氏锥虫和弓形虫靶向法呢基二磷酸合酶的新型 2-烷基氨基乙基-1,1-双膦酸的合成和生物学评价

  摘要：

  研究了长链 2-烷基氨基乙基-1,1-二膦酸盐对临床上更相关的克氏锥虫（美国锥虫病（南美锥虫病）的病原体）增殖和弓形虫速殖子的作用。特别是，化合物26被证明是一种针对细胞内形式的克氏锥虫的极其有效的抑制剂，其IC 50值在纳摩尔范围内。这种细胞活性与对克氏锥虫法呢基二磷酸合酶 ( Tc FPPS)的酶活性的强烈抑制有关，后者构成了恰加斯病化疗的有效靶点。化合物26是一种有效的抗克氏锥虫（无鞭毛体）药物，其 IC 50值为 0.67 μM，而该化合物对靶酶Tc FPPS的 IC 50值为 0.81 μM 。该药物对T. cruzi茄尼基二磷酸合酶Tc SPPS的酶活性效果较差，IC 50值为 3.2 μM。有趣的是，化合物26对弓形虫（速殖子）也非常有效，IC 50值为 6.23 μM。这种细胞活性也与对靶酶Tg的酶活性的抑制有关。FPPS (IC 50  = 0.093 μM) 由于含双膦酸盐的化合物是

  DOI：

  10.1016/j.bmc.2011.02.037

文献信息

• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。
• NON-TOXIC CORROSION PROTECTION PIGMENTS BASED ON COBALT
  申请人：UNIVERSITY OF DAYTON

  公开号：EP1472319A1

  公开（公告）日：2004-11-03
• Non-toxic corrosion-protection rinses and seals based on rare earth elements
  申请人：——

  公开号：US20040016910A1

  公开（公告）日：2004-01-29

  Rinsing or sealing solutions comprising a rare earth element and a valence stabilizer for barrier films. The treated films contain a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, praseodymium, terbium, or combinations thereof, and at least one rare earth element is in the tetravalent oxidation state. The rinsing or sealing solution may also contain an optional preparative or solubility control agent. The oxidized rare earth element is present in the coating in a “sparingly soluble” form. The valence stabilizers can be either inorganic or organic in nature. A number of rare earth/valence stabilizer combinations that match the performance of conventional hexavalent chromium systems are presented.
• NON-TOXIC CORROSION-PROTECTION PIGMENTS BASED ON MANGANESE
  申请人：Sturgill A. Jeffrey

  公开号：US20070149673A1

  公开（公告）日：2007-06-28

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 C.F.R. § 1.72(b).
• NON-TOXIC CORROSION-PROTECTION PIGMENTS BASED ON COBALT
  申请人：Sturgill Jeffrey Allen

  公开号：US20090163628A1

  公开（公告）日：2009-06-25

  Corrosion-inhibiting pigments based on cobalt are described that contain a trivalent or tetravalent cobalt/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent cobalt ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent cobalt during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Cobalt/valence stabilizer combinations are chosen based on the well-founded principles of cobalt coordination chemistry. Many cobalt-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.