1-[4-({1-methyl-4-[(1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)phenyl]-3-pyridin-3-ylurea | 1204594-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1-[4-({1-methyl-4-[(1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)phenyl]-3-pyridin-3-ylurea
• 英文别名: 1-[4-[[1-Methyl-4-[(1-oxo-2,3-dihydroisoindol-5-yl)amino]pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-3-pyridin-3-ylurea
• CAS: 1204594-75-1
• 化学式: C₂₆H₂₂N₁₀O₂
• 分子量: 506.526
• InChiKey: ODRAPXLRFSJMCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• 4-PHENOXY-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE AND N-ARYL-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
  申请人：Bursavich Matthew Gregory

  公开号：US20100015141A1

  公开（公告）日：2010-01-21

  The invention relates to 4,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds, including 4-phenoxy-6-aryl-1H-pyrazolo[3,4-d]pyrimidine and N-aryl-6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

  本发明涉及4,6-二取代-1H-吡唑[3,4-d]嘧啶-4-胺化合物，包括4-苯氧基-6-芳基-1H-吡唑[3,4-d]嘧啶和N-芳基-6-芳基-1H-吡唑[3,4-d]嘧啶-4-胺的化合物，其化学式为I： 或其药用可接受盐，其中组成变量如本文所述，包含该化合物的组合物，以及制造和使用这些化合物的方法。
• [EN] 4-PHENOXY-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE AND N-ARYL-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES<br/>[FR] COMPOSÉS 4-PHÉNOXY-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE ET N-ARYL-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE-4-AMINE, LEUR UTILISATION COMME INHIBITEURS DE LA MTOR KINASE ET DE LA PI3 KINASE, ET LEURS SYNTHÈSES
  申请人：WYETH CORP

  公开号：WO2010011620A1

  公开（公告）日：2010-01-28

  The invention relates to 4,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds, including 4-phenoxy-6-aryl-1H-pyrazolo[3,4-d]pyrimidine and N-aryl-6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.