Ethanamine, N-methyl-2-(pentyloxy)- | 1250810-29-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Ethanamine, N-methyl-2-(pentyloxy)-
• 英文别名: N-methyl-2-pentoxyethanamine
• CAS: 1250810-29-7
• 化学式: C₈H₁₉NO
• 分子量: 145.24
• InChiKey: GXYRDBQSBQRTKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] BIFUNCTIONAL SUBSTITUED PYRIMIDINES AS MODULATORS OF FAK PROTEOLYSE<br/>[FR] PYRIMIDINES SUBSTITUÉES BIFONCTIONNELLES EN TANT QUE MODULATEURS DU PROTÉOLYSE DE FAK
  申请人：UNIV YALE

  公开号：WO2020023851A1

  公开（公告）日：2020-01-30

  The present disclosure relates to bifunctional compounds, which find utility as modulators of focal adhesion kinase (FAK) or protein tyrosine kinase 2 (PTK2). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为调节焦粘附激酶（FAK）或蛋白酪氨酸激酶2（PTK2）的调节剂。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源物2配体的双功能化合物，该配体结合到相应的E3泛素连接酶，另一端为结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• A COMPOSITION FOR USE IN WASHING AND CLEANSING VULCANIZATION MOLDS
  申请人：SAN MARTINO S.P.A.

  公开号：EP0576445B1

  公开（公告）日：1996-05-15
• SUBSTITUIERTE THIOPHENYLURACILE SOWIE DEREN SALZE UND IHRE VERWENDUNG ALS HERBIZIDE WIRKSTOFFE
  申请人：Syngenta Crop Protection AG

  公开号：EP3728237B1

  公开（公告）日：2022-02-09
• ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS
  申请人：Nuvation Bio Inc.

  公开号：US20210214316A1

  公开（公告）日：2021-07-15

  The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.
• US5468422A
  申请人：——

  公开号：US5468422A

  公开（公告）日：1995-11-21