dimyristoyl phosphatidylcholine | 71900-56-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: dimyristoyl phosphatidylcholine
• 英文别名: DMPC;L-beta,gamma-Dimyristoyl-alpha-lecithin；2-[2,3-di(tetradecanoyloxy)propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium
• CAS: 71900-56-6
• 化学式: C₃₆H₇₃NO₈P
• 分子量: 678.951
• InChiKey: CITHEXJVPOWHKC-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  11.4
• 重原子数：
  46
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• C<SB>70</SB>-CONTAINING LIPOSOME, METHOD FOR PRODUCING THE SAME, AND USE OF THE SAME
  申请人：National University Corporation Nara Institute of Science and Technology

  公开号：EP2123288A1

  公开（公告）日：2009-11-25

  A solution containing a C70 cyclodextrin complex and a solution containing a lipid that is capable of forming a liposome are mixed together at a temperature in a range of 10 °C to 45 °C. This produces a C70-incorporated liposome which keeps a physical property that the C70 fullerene originally has, and is stably solubilized in a polar solvent. Hence, the present invention provides a C70-incorporated liposome which keeps a physical property that the C70 fullerene originally has, and which is stably solubilized in a polar solvent, a production method of the same, and a use of the same.

  将含有 C70 环糊精复合物的溶液和含有可形成脂质体的脂质的溶液在 10 °C 至 45 °C 的温度范围内混合在一起。这样得到的 C70 嵌入脂质体保持了 C70 富勒烯原有的物理特性，并能稳定地溶解在极性溶剂中。因此，本发明提供了一种保持 C70 富勒烯原有物理特性并能在极性溶剂中稳定溶解的 C70 包裹脂质体、其生产方法和用途。
• LIPOSOMAL NANOCARRIER DELIVERY SYSTEM FOR TARGETING ACTIVE CD44 MOLECULE, PREPARATION METHOD THEREFOR, AND USES THEREOF
  申请人：Beijing Inno Medicine Co., Ltd.

  公开号：EP3744317A1

  公开（公告）日：2020-12-02

  A liposomal nanocarrier delivery system for targeting an active CD44 molecule, preparation method therefor, and uses thereof. The surface of the liposome is partially modified by a targeting ligand, wherein the targeting ligand is a ligand that can be specifically combined with the active CD44 molecule. The liposomal nanocarrier delivery system can be used for diagnosing, preventing, and treating vulnerable plaque or diseases related to vulnerable plaque.

  一种用于靶向活性 CD44 分子的脂质体纳米载体递送系统、其制备方法及其用途。脂质体的表面部分被靶向配体修饰，其中靶向配体是可与活性 CD44 分子特异性结合的配体。该脂质体纳米载体递送系统可用于诊断、预防和治疗易损斑块或与易损斑块相关的疾病。
• OPHTHALMIC PHARMACEUTICAL COMPOSITION, PREPARATION METHODS AND USES OF SAME
  申请人：Sophia Holdings, S.A. de C.V.

  公开号：EP4026538A1

  公开（公告）日：2022-07-13

  The present invention relates to ophthalmic compositions in the form of oil-in-water (O/W) nano-emulsions, and which mainly comprise propylene glycol and sodium hyaluronate. The invention also relates to preparation methods and uses of the artificial tear compositions.

  本发明涉及水包油（O/W）纳米乳剂形式的眼科组合物，其中主要包括丙二醇和透明质酸钠。本发明还涉及人工泪液组合物的制备方法和用途。
• Bi-directionally crosslinked liposomes and method of making same
  申请人：Verily Life Sciences LLC

  公开号：US10842746B1

  公开（公告）日：2020-11-24

  Disclosed herein are methods for producing bi-directionally crosslinked liposomes. The methods include the steps of: providing a lipid composition comprising a plurality of reactive lipids, wherein each of the reactive lipids comprises a reactive hydrophobic group, a reactive hydrophilic group, or a reactive hydrophilic group and a reactive hydrophobic group; forming an un-crosslinked liposome comprising the reactive lipids; and crosslinking at least a portion of the reactive hydrophobic groups or the reactive hydrophilic groups; thereby producing the bi-directionally crosslinked liposomes. Bi-directionally crosslinked liposomes and methods for delivering therapeutic and/or diagnostic agents to subjects using the liposomes are also described.

  本文公开了生产双向交联脂质体的方法。这些方法包括以下步骤：提供包含多种活性脂质的脂质组合物，其中每种活性脂质包含一个活性疏水基团、一个活性亲水基团或一个活性亲水基团和一个活性疏水基团；形成包含活性脂质的未交联脂质体；交联至少一部分活性疏水基团或活性亲水基团；从而生产双向交联脂质体。此外，还描述了双向交联脂质体和使用该脂质体向受试者递送治疗和/或诊断制剂的方法。
• LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL
  申请人：SDG, Inc.

  公开号：EP1883394B1

  公开（公告）日：2018-03-28