(E)-2'-deoxy-2'-fluoromethylideneguanosine | 130306-12-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (E)-2'-deoxy-2'-fluoromethylideneguanosine
• 英文别名: 2-amino-9-[(2R,3E,4S,5R)-3-(fluoromethylidene)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• CAS: 130306-12-6
• 化学式: C₁₁H₁₂FN₅O₄
• 分子量: 297.246
• InChiKey: JBPFFLQXZFZBID-YCFCVGDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  135
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Novel 2'-halomethylidene, 2'-ethenylidene and 2'ethynyl cytidine, uridine and guanosine derivatives
  申请人：——

  公开号：US20030109484A1

  公开（公告）日：2003-06-12

  This invention relates to certain novel 2′-halomethylidene, 2′-ethenylidene and 2′-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.

  本发明涉及某些新型 2′-亚甲基、2′-亚乙烯基和 2′-乙炔基胞苷、尿苷和鸟苷衍生物及其组合物，可用于治疗肿瘤性或病毒性疾病患者。
• Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
  申请人：Merrell Pharmaceuticals Inc.

  公开号：US20040063659A1

  公开（公告）日：2004-04-01

  This invention relates to certain novel 2′-halomethylidene, 2′-ethenylidene and 2′-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.

  本发明涉及某些新型 2′-亚甲基、2′-亚乙烯基和 2′-乙炔基胞苷、尿苷和鸟苷衍生物及其组合物，可用于治疗肿瘤性或病毒性疾病患者。
• Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0372268B1

  公开（公告）日：1994-05-04
• COMPOSITIONS CONTAINING ACYCLOVIR-LIKE COMPOUNDS AND 2'-VINYL SUBSTITUTED NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：MERRELL PHARMACEUTICALS INC.

  公开号：EP0671918B1

  公开（公告）日：1997-05-28
• US5607925A
  申请人：——

  公开号：US5607925A

  公开（公告）日：1997-03-04