(17Z)-5β-pregn-17(20)-en-3α-ol | 21338-13-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (17Z)-5β-pregn-17(20)-en-3α-ol
• 英文别名: 3α-hydroxy-10.13-dimethyl-17-(ethylidene-(ξ))-5β-gonane；(10S)-3t-Hydroxy-10r.13c-dimethyl-17-(aethyliden-(ξ))-(5cH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；3α-Hydroxy-10.13-dimethyl-17-(aethyliden-(ξ))-5β-gonan；(3R,5R,8R,9S,10S,13S,14S)-17-ethylidene-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-ol
• CAS: 21338-13-6
• 化学式: C₂₁H₃₄O
• 分子量: 302.5
• InChiKey: PETCQLIYOLSRPS-YJUFFEMBSA-N

物化性质

• 沸点：
  402.8±45.0 °C(Predicted)
• 密度：
  1.049±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (17Z)-5β-pregn-17(20)-en-3α-ol 在 四氧化锇 、 乙醚 作用下， 生成 (20R)-5beta-孕甾烷-3alpha,17,20-三醇
  参考文献：
  名称：

  Preschoolers' Inhibition in Their Home: Relation to Temperament

  摘要：

  Researchers assessed 58 preschoolers' reactions to an unfamiliar person and unfamiliar objects in their familiar home environment. Children participated in a 30-min procedure designed to elicit behavioral inhibition, including (a) a free-play period with a stranger present, (b) a structured interaction with the stranger, and (c) uncertainty-eliciting tasks, Behaviors representing the child's reactions toward the mother, stranger, and novel objects were coded, Mothers completed a temperament scale. Preschoolers exhibited behaviors indicative of inhibition toward unfamiliar social and nonsocial stimuli; behaviors remained stable across increasingly intrusive episodes. The approach/withdrawal component of temperament was related to behavioral inhibition. Individual differences in mood did not appear to be related to differences in inhibition. Parent reported temperament was related to researcher-observed behaviors.

  DOI：

  10.1080/00221320209598688
• 作为产物：
  描述：

  吡啶 、 alkaline earth salt of/the/ methylsulfuric acid 在 calcium carbonate 作用下， 生成 (17Z)-5β-pregn-17(20)-en-3α-ol
  参考文献：
  名称：

  Preschoolers' Inhibition in Their Home: Relation to Temperament

  摘要：

  Researchers assessed 58 preschoolers' reactions to an unfamiliar person and unfamiliar objects in their familiar home environment. Children participated in a 30-min procedure designed to elicit behavioral inhibition, including (a) a free-play period with a stranger present, (b) a structured interaction with the stranger, and (c) uncertainty-eliciting tasks, Behaviors representing the child's reactions toward the mother, stranger, and novel objects were coded, Mothers completed a temperament scale. Preschoolers exhibited behaviors indicative of inhibition toward unfamiliar social and nonsocial stimuli; behaviors remained stable across increasingly intrusive episodes. The approach/withdrawal component of temperament was related to behavioral inhibition. Individual differences in mood did not appear to be related to differences in inhibition. Parent reported temperament was related to researcher-observed behaviors.

  DOI：

  10.1080/00221320209598688

文献信息

• A New Class of Potent <i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications
  作者：Eva Kudova、Hana Chodounska、Barbora Slavikova、Milos Budesinsky、Michaela Nekardova、Vojtech Vyklicky、Barbora Krausova、Pavel Svehla、Ladislav Vyklicky

  DOI：10.1021/acs.jmedchem.5b00570

  日期：2015.8.13

  promising therapeutic targets. In this study, we describe a new class of neurosteroid analogues which possess structural modifications in the steroid D-ring region. These analogues were tested on recombinant GluN1/GluN2B receptors to evaluate the structure–activity relationship. Our results demonstrate that there is a strong correlation between this new structural feature and the in vitro activity, as all

  Ñ -甲基- d天门冬氨酸受体（NMDARs）是谷氨酸门控离子通道，在兴奋性突触传递中起关键作用。但是，NMDAR的过度激活可能导致兴奋性毒性细胞损伤/死亡，因此，它们在许多神经病理学疾病中发挥作用。已知NMDAR的活性受多种变构调节剂（包括神经甾体）的影响，这反过来又使它们成为有希望的治疗靶标。在这项研究中，我们描述了一类新的类固醇神经类似物，在类固醇D环区域具有结构修饰。这些类似物在重组GluN1 / GluN2B受体上进行了测试，以评估其结构与活性之间的关系。我们的结果表明，这种新的结构特征与体外活性之间存在很强的相关性，与已知的内源性神经甾体-孕烯醇酮硫酸盐（IC 50 = 24.6μM）相比，有50个值在90 nM至5.4μM之间变化。