[1-[(2S)-2-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methyl (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-[2-[[1-[(2S)-2-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methoxy]acetyl]oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate | 1316673-01-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [1-[(2S)-2-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methyl (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-[2-[[1-[(2S)-2-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methoxy]acetyl]oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
• CAS: 1316673-01-4
• 化学式: C₅₈H₉₈N₁₂O₉
• 分子量: 1107.49
• InChiKey: KYVZXQLDLGGZLN-RAVPNJBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  79
• 可旋转键数：
  29
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  292
• 氢给体数：
  6
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  [1-[(2S)-2-[[2-[(2,4-dimethoxyphenyl)methyl-[(2S,3S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methyl (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-[2-[[1-[(2S)-2-[[2-[(2,4-dimethoxyphenyl)methyl-[(2S,3S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methoxy]acetyl]oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate 在 三氟乙酸 作用下， 反应 7.0h， 以60%的产率得到[1-[(2S)-2-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methyl (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-[2-[[1-[(2S)-2-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-2-methylpropanoyl]amino]propyl]triazol-4-yl]methoxy]acetyl]oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
  参考文献：
  名称：

  Design and synthesis of bile acid–peptide conjugates linked via triazole moiety

  摘要：

  通过 Cu（I）催化的点击化学，描述了胆汁酸与肽的共轭。利用 Cu(I)-catalyzed 1,3-dipolar cycloaddition ("click "反应)，合成了基于胆酸、去氧胆酸和石胆酸衍生物的通过 1,2,3- 三唑分子连接的新型胆酸肽共轭物。研究表明，多达三个肽片段可以连接到一个中央甾体核心，从而形成复杂的三维多共轭结构，在生物化学、药物化学和配位化学中具有重要的应用价值。

  DOI：

  10.1039/c0ob01188f

文献信息

• Design and synthesis of bile acid–peptide conjugates linked via triazole moiety
  作者：Nadezhda V. Sokolova、Gennadij V. Latyshev、Nikolay V. Lukashev、Valentine G. Nenajdenko

  DOI：10.1039/c0ob01188f

  日期：——

  A conjugation of bile acids with peptidesviaCu(I)-catalyzed click chemistry has been described. Novel bile acid–peptide conjugates linked via a 1,2,3-triazole moiety based on cholic, deoxycholic and lithocholic acid derivatives were synthesized using Cu(I)-catalyzed 1,3-dipolar cycloaddition (“click” reaction). It was shown that up to three peptide fragments can be attached to a central steroid core, thus forming complex three-dimensional polyconjugate structures, which can find important applications in biochemistry, medicinal chemistry, and coordination chemistry.

  通过 Cu（I）催化的点击化学，描述了胆汁酸与肽的共轭。利用 Cu(I)-catalyzed 1,3-dipolar cycloaddition ("click "反应)，合成了基于胆酸、去氧胆酸和石胆酸衍生物的通过 1,2,3- 三唑分子连接的新型胆酸肽共轭物。研究表明，多达三个肽片段可以连接到一个中央甾体核心，从而形成复杂的三维多共轭结构，在生物化学、药物化学和配位化学中具有重要的应用价值。