1-(2-Fluoro-4-nitrophenyl)-4-imidazolidinone | 693787-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-Fluoro-4-nitrophenyl)-4-imidazolidinone
• 英文别名: 1-(2-fluoro-4-nitrophenyl)imidazolidin-4-one
• CAS: 693787-68-7
• 化学式: C₉H₈FN₃O₃
• 分子量: 225.179
• InChiKey: BHCRIUJVXHOCEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  78.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-咪唑烷酮 、 3,4-二氟硝基苯 、 N,N-二异丙基乙胺 在 氩 、 ice 、 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以to yield the nitro compound (19.5 g, 78.5%) as yellow crystals的产率得到1-(2-Fluoro-4-nitrophenyl)-4-imidazolidinone
  参考文献：
  名称：

  Salts of novel heterocyclic compounds having antibacterial activity

  摘要：

  本发明涉及公式（I）的新型噁唑啉酮化合物、它们的立体异构体、它们的盐以及含有它们的制药组合物。本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐以及制药组合物的方法。

  公开号：

  US20070004712A1

文献信息

• Novel heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Laboratories Limited

  公开号：US20040102494A1

  公开（公告）日：2004-05-27

  The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. 1 The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions.

  本发明涉及新型噁唑啉酮化合物(I)、它们的立体异构体、它们的盐以及含有它们的药物组合物。此外，本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐以及药物组合物的方法。
• Intermediates of novel heterocyclic compounds having antibacterial activity and process for their preparation
  申请人：Selvakumar Natesan

  公开号：US20060293315A1

  公开（公告）日：2006-12-28

  The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions.

  本发明涉及式(I)的新型噁唑啉化合物，它们的立体异构体，它们的盐和含有它们的药物组成物。本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐和药物组成物的方法。
• Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
  申请人：Dr.Reddy's Laboratories Ltd.

  公开号：US07160912B2

  公开（公告）日：2007-01-09

  The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions.

  本发明涉及一种新型噁唑啉化合物（I）及其立体异构体、其盐和含有它们的制药组合物。本发明还涉及一种制备上述新型化合物、其立体异构体、其盐和制药组合物的方法。
• US7160912B2
  申请人：——

  公开号：US7160912B2

  公开（公告）日：2007-01-09