S-5-(9H-carbazol-9-yl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate | 1101207-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: S-5-(9H-carbazol-9-yl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate
• CAS: 1101207-07-1
• 化学式: C₂₃H₂₆N₂O₃S₂
• 分子量: 442.603
• InChiKey: NUKUKGYJAJCTOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.05
• 重原子数：
  30.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  52.82
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  S-5-(9H-carbazol-9-yl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate 在 过氧化双月桂酰 作用下， 以 氯苯 为溶剂， 反应 3.0h， 以40%的产率得到4-((propan-2-ylideneaminooxy)methyl)-5,6-dihydroazepino[3,2,1-jk]carbazol-7(4H)-one
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113
• 作为产物：
  描述：

  acetoxime O-allyl ether 、 O-ethyl (2-carbazol-9-yl-2-oxoethyl)sulfanylmethanethioate 在 过氧化双月桂酰 作用下， 以 1,2-二氯乙烷 为溶剂， 以84%的产率得到S-5-(9H-carbazol-9-yl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113