(1S,2R)-2-(thiophen-3-yl)-1,2-dihydronaphthalen-1-ol | 1505513-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: (1S,2R)-2-(thiophen-3-yl)-1,2-dihydronaphthalen-1-ol
• CAS: 1505513-90-5
• 化学式: C₁₄H₁₂OS
• 分子量: 228.315
• InChiKey: HLDQZGZTHKKLQI-ZIAGYGMSSA-N

反应信息

• 作为产物：
  描述：

  3-噻吩硼酸 、 1,4-epoxy-1,4-dihydronaphthalene 在 (R)-(+)-5,5'-双[二(3,5-二甲苯基)膦]-4,4'-二-1,3-苯并二茂 、 dichloro( 1,5-cyclooctadiene)platinum(ll) 、 potassium fluoride 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 96.0h， 以75%的产率得到
  参考文献：
  名称：

  Platinum(II)-Catalyzed Asymmetric Ring-Opening Addition of Arylboronic Acids to Oxabenzonorbornadienes

  摘要：

  A new platinum(II)-catalyzed asymmetric ring-opening addition of arylboronic acids to oxabenzonorbornadienes was developed, which afforded the corresponding cis-2-aryl-1,2-dihydronaphthalen-1-ol products in high yields (up to 97%) with moderate to good enantioselectivities (up to 89% ee) under very mild conditions. The effects of various ligands, catalyst loading, bases, solvents, and temperatures on the yield and enantioselectivity of the reaction were also investigated. The cis configuration of product 2m was confirmed by X-ray diffraction analysis. A potential mechanism for the present catalytic reaction is proposed.

  DOI：

  10.1021/jo402386k