2-bromo-1-hexylindolactam-V10 | 1004551-07-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 2-bromo-1-hexylindolactam-V10
• 英文别名: (3S,6S)-10-bromo-11-hexyl-6-(hydroxymethyl)-2-methyl-3-propan-2-yl-2,5,11-triazatricyclo[7.6.1.012,16]hexadeca-1(15),9,12(16),13-tetraen-4-one
• CAS: 1004551-07-8
• 化学式: C₂₄H₃₆BrN₃O₂
• 分子量: 478.473
• InChiKey: VWIUYGBEDVPHRK-JTSKRJEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-hexyl-indolactam-V10 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以46%的产率得到2-bromo-1-hexylindolactam-V10
  参考文献：
  名称：

  Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexylindolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes

  摘要：

  Conventional and novel protein kinase C (PKC) isozymes are the main targets of tumor promoters. We developed 1-hexylindolactam-V10 (5) as a selective activator for novel PKC isozymes that play important roles in various cellular processes related to tumor promotion, ischemia-reperfusion injury in the heart, and Alzheimer's disease. The compound existed as a mixture of three conformers. The trans-amide restricted analogues of 5 (14 and 15) hardly bound to PKC isozymes, suggesting that the active conformation of 5 could be that with a cis-amide. Compound 5 selectively translocated novel PKC isozymes over conventional PKC isozymes in HeLa cells at 0.1-1 mu M. These results suggest that 5 could be useful for the functional analysis of novel PKC isozymes.

  DOI：

  10.1021/jm0706719