2-chloro-12b-(trifluoromethyl)-5,6-dihydroisoindolo[1,2-a]isoquinolin-8(12bH)-one | 1598385-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-chloro-12b-(trifluoromethyl)-5,6-dihydroisoindolo[1,2-a]isoquinolin-8(12bH)-one
• CAS: 1598385-82-0
• 化学式: C₁₇H₁₁ClF₃NO
• 分子量: 337.729
• InChiKey: YVZRTGQDIGMHTF-UHFFFAOYSA-N

物化性质

• 熔点：
  158-160 °C
• 沸点：
  432.1±45.0 °C(predicted)
• 密度：
  1.50±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  在 甲烷磺酸 作用下， 以 1,2-二氯乙烷 为溶剂， 以63 mg的产率得到2-chloro-12b-(trifluoromethyl)-5,6-dihydroisoindolo[1,2-a]isoquinolin-8(12bH)-one
  参考文献：
  名称：

  One-Pot Cascade Trifluoromethylation/Cyclization of Imides: Synthesis of α-Trifluoromethylated Amine Derivatives

  摘要：

  Tryptamine- and phenethylamine-derived imides were selectively monotrifluoromethylated using CF3TMS. Subsequent methanesulfonic acid mediated cyclization of the intermediate hemiaminals afforded the alpha-trifluoromethylated amine derivatives via the formation of trifluoromethylated acyliminium ions, in one pot. The strategy was applicable to the both inter- and intramolecular versions. Furthermore, the utility of the present method was demonstrated through the synthesis of trifluoromethylated analogues of harmicine and crispine A.

  DOI：

  10.1021/jo5002998