(S)-pentafluoroethanesulfinamide | 1303994-30-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 亚磺酸及其衍生物
• 英文名称: (S)-pentafluoroethanesulfinamide
• 英文别名: (S)-1,1,2,2,2-pentafluoroethanesulfinamide
• CAS: 1303994-30-0
• 化学式: C₂H₂F₅NOS
• 分子量: 183.102
• InChiKey: RONIZBKHCXFHAM-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.3
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (R(S),4S)-4-phenyl-N-(pentafluoroethanesulfinyl)oxazolidin-2-one 在 lithium hexamethyldisilazane 、 氯化铵 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.0h， 以67%的产率得到(S)-pentafluoroethanesulfinamide
  参考文献：
  名称：

  Optically Pure Polyfluoroalkanesulfinamides: Synthesis and Application as Promising and Monitorable Chiral Auxiliaries

  摘要：

  Efficient synthesis of enantiopure polyfluoroalkanesulfinamides (PFSAs) has been achieved. Their application as novel chiral auxiliaries with an electron-withdrawing and F-19 NMR monitorable polyfluoroalkyl group was initially demonstrated in an asymmetric Strecker reaction under mild conditions.

  DOI：

  10.1021/jo200119x

文献信息

• Optically Pure Polyfluoroalkanesulfinamides: Synthesis and Application as Promising and Monitorable Chiral Auxiliaries
  作者：Li-Juan Liu、Ling-Jun Chen、Peng Li、Xiao-Bo Li、Jin-Tao Liu

  DOI：10.1021/jo200119x

  日期：2011.6.3

  Efficient synthesis of enantiopure polyfluoroalkanesulfinamides (PFSAs) has been achieved. Their application as novel chiral auxiliaries with an electron-withdrawing and F-19 NMR monitorable polyfluoroalkyl group was initially demonstrated in an asymmetric Strecker reaction under mild conditions.