1,1'-biphenyl-4-yl (1S,3S)-1-(1,1'-biphenyl-4-yl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxamide | 515157-04-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 1,1'-biphenyl-4-yl (1S,3S)-1-(1,1'-biphenyl-4-yl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxamide
• 英文别名: (1S,3S)-N,1-bis(4-phenylphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
• CAS: 515157-04-7
• 化学式: C₃₆H₂₉N₃O
• 分子量: 519.646
• InChiKey: LCCOBDHWVMOHSP-HEVIKAOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  40
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  56.9
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED BETA AMINO ACID DERIVATIVES<br/>[FR] PROCEDE POUR LA PREPARATION DE DERIVES D'ACIDES AMINES BETA A ENRICHISSEMENT ENANTIOMERIQUE
  申请人：MERCK & CO INC

  公开号：WO2005097733A1

  公开（公告）日：2005-10-20

  The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.

  本发明涉及一种高效制备对映富集的β-氨基酸衍生物的过程，其中氨基未受保护。所得的手性β-氨基酸衍生物在生物活性分子的不对称合成中很有用。该过程包括在铑金属前体与手性单膦或双膦配体络合物的存在下对氨基未受保护的丙烯酸β-氨基或其衍生物进行对映选择性的氢化。
• Heteroaryl - fused nitrogen heterocycles as therapeutic agents
  申请人：Mjalli M. M. Adnan

  公开号：US20050096335A1

  公开（公告）日：2005-05-05

  This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases, the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPase activity. Such diseases include type I diabetes, type II diabetes, immune dysfunction, AIDS, autoimmunity, glucose intolerance, obesity, cancer, psoriasis, allergic diseases, infectious diseases, inflammatory diseases, diseases involving the modulated synthesis of growth hormone or the modulated synthesis of growth factors or cytokines which affect the production of growth hormone, or Alzheimer's disease.

  本发明提供了可用作蛋白酪氨酸磷酸酶（PTPase）抑制剂的化合物。作为 PTP 酶的抑制剂，本发明的化合物可用于管理、治疗、控制和辅助治疗由 PTP 酶活性介导的疾病。这些疾病包括 I 型糖尿病、II 型糖尿病、免疫功能障碍、艾滋病、自身免疫、葡萄糖不耐受症、肥胖症、癌症、牛皮癣、过敏性疾病、传染性疾病、炎症性疾病、涉及生长激素合成调节或影响生长激素产生的生长因子或细胞因子合成调节的疾病或阿尔茨海默病。
• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED BETA AMINO ACID DERIVATIVES
  申请人：Merck & Co., Inc.

  公开号：EP1735269A1

  公开（公告）日：2006-12-27