3-benzo[1,3]dioxol-5-yl-2-hydroxy-N-[2-hydroxy-3-(naphthalen-1-yloxy)-propyl]-propionamide | 1151509-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-benzo[1,3]dioxol-5-yl-2-hydroxy-N-[2-hydroxy-3-(naphthalen-1-yloxy)-propyl]-propionamide
• 英文别名: 3-(1,3-benzodioxol-5-yl)-2-hydroxy-N-(2-hydroxy-3-naphthalen-1-yloxypropyl)propanamide
• CAS: 1151509-67-9
• 化学式: C₂₃H₂₃NO₆
• 分子量: 409.439
• InChiKey: IGZBSQSDMKEFJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  97.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(3,4-methylenedioxyphenyl)-2-hydroxypropanoic acid 、 N-去异丙基普萘洛尔 在 4-二甲氨基吡啶 N,N'-二环己基碳二亚胺 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以32.8%的产率得到3-benzo[1,3]dioxol-5-yl-2-hydroxy-N-[2-hydroxy-3-(naphthalen-1-yloxy)-propyl]-propionamide
  参考文献：
  名称：

  SUBSTITUTED BETA-PHENYL-ALPHA-HYDROXY PROPANOIC ACID, SYNTHESIS METHOD AND USE THEREOF

  摘要：

  公开号：

  EP2019090B1

文献信息

• SUBSTITUTED BETA-PHENYL-ALPHA-HYDROXY-PROPANOIC ACID, SYNTHESIS METHOD AND USE THEREOF
  申请人：Zheng Xiaohui

  公开号：US20090131677A1

  公开（公告）日：2009-05-21

  The present invention relates to a compound of the formula (I), wherein R 1 , R 2 and R 3 are each independently selected from H, OH, F, Cl, Br, methoxy and ethoxy; or alternatively, R 1 and R 2 together form —OCH 2 O—, R 3 is selected from H, OH, methoxy, ethoxy and halogens; R 4 is OH or acyloxy; R 5 is cycloalkoxyl, amino and substituted amino, and when R 5 is selected from amino, at least one of R 1 , R 2 and R 3 is not H. The present invention further relates to a process for synthesizing a compound of the formula (I), and use of the compound of the formula (I) in the manufacture of a medicament for the prevention or treatment of cardiovascular or cerebrovascular diseases.

  本发明涉及公式（I）的化合物，其中R1、R2和R3各自独立地选自H、OH、F、Cl、Br、甲氧基和乙氧基；或者，R1和R2一起形成-OCH2O-，R3选自H、OH、甲氧基、乙氧基和卤素；R4为OH或酰氧基；R5为环烷氧基、氨基和取代氨基，当R5选自氨基时，至少有R1、R2和R3中的一个不是H。本发明还涉及合成公式（I）化合物的方法，以及使用公式（I）化合物制造用于预防或治疗心血管或脑血管疾病的药物。
• Substituted beta-phenyl-alpha-hydroxy propanoic acid, synthesis method and use thereof
  申请人：Northwest University

  公开号：EP2514739A1

  公开（公告）日：2012-10-24

  The present invention relates to a compound of the formula (I), wherein R1, R2 and R3 are each independently selected from H, OH, F, Cl, Br, methoxy and ethoxy; or alternatively, R1 and R2 together form -OCH2O-, R3 is selected from H, OH, methoxy, ethoxy and halogens; R4 is OH or acyloxy; R5 is cycloalkoxyl, amino and substituted amino, and when R5 is selected from amino, at least one of R1, R2 and R3 is not H. The present invention further relates to a process for synthesizing a compound of the formula (I), and use of the compound of the formula (I) in the manufacture of a medicament for the prevention or treatment of cardiovascular or cerebrovascular diseases.

  本发明涉及一种式(I)化合物，其中R1、R2和R3各自独立地选自H、OH、F、Cl、Br、甲氧基和乙氧基；或者，R1和R2一起形成-OCH2O-，R3选自H、OH、甲氧基、乙氧基和卤素；R4是OH或酰氧基；R5是环烷氧基、氨基和取代氨基，当R5选自氨基时，R1、R2和R3中至少有一个不是H。本发明进一步涉及一种合成式（I）化合物的工艺，以及式（I）化合物在制造预防或治疗心脑血管疾病的药物中的用途。
• US8017786B2
  申请人：——

  公开号：US8017786B2

  公开（公告）日：2011-09-13