4-methyl-N-[2-(trifluoromethyl)-9H-fluoren-9-yl]benzenesulfonamide | 1304461-17-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 4-methyl-N-[2-(trifluoromethyl)-9H-fluoren-9-yl]benzenesulfonamide
• CAS: 1304461-17-3
• 化学式: C₂₁H₁₆F₃NO₂S
• 分子量: 403.425
• InChiKey: RCKPLOPYEXCQDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-methyl-N-[[2-[4-(trifluoromethyl)phenyl]phenyl]methylidene]benzenesulfonamide 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 甲苯 为溶剂， 以94%的产率得到4-methyl-N-[2-(trifluoromethyl)-9H-fluoren-9-yl]benzenesulfonamide
  参考文献：
  名称：

  Facile Cu(OTf)2-catalyzed preparation of 9-tosylaminofluorene derivatives from o-arylated N-tosylbenzaldimines

  摘要：

  The 9-tosylaminofluorene derivatives were synthesized conveniently by Cu(OTf)(2)-catalyzed aza-Friedel-Crafts reaction of o-arylated N-tosylbenzaldimines in high yields. This is an efficient, atom-economic, and green method. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.110

文献信息

• Lewis acid-catalyzed tandem synthesis of 9-sulfonylamino- and 9-arylfluorenes
  作者：Dayun Huang、Weiguang Yang、Jianlan Zhang、Xuesong Wang、Xinyan Wang、Yuefei Hu

  DOI：10.1039/c6ra03889a

  日期：——

  A Lewis acid-catalyzed three-step tandem synthesis of 9-arylfluorene was developed by simply heating a mixture of 2-formyl biphenyl, TsNCO and an arene. In the absence of arene, a two-step tandem synthesis of 9-sulfonylaminofluorene was achieved. These advances were mainly attributed to the discovery of an anhydrous synthesis of N-tosyl arylaldimines from TsNCO and arylaldehydes.

  通过简单地加热2-甲酰基联苯，TsNCO和芳烃的混合物，开发了路易斯酸催化的三步串联合成9-芳基芴的方法。在没有芳烃的情况下，实现了两步串联的9-磺酰基氨基芴的合成。这些进展主要归因于从TsNCO和芳基醛无水合成N-甲苯磺酰基芳基亚胺的发现。
• Facile Cu(OTf)2-catalyzed preparation of 9-tosylaminofluorene derivatives from o-arylated N-tosylbenzaldimines
  作者：Xufen Yu、Xiyan Lu

  DOI：10.1016/j.tetlet.2010.10.110

  日期：2011.4

  The 9-tosylaminofluorene derivatives were synthesized conveniently by Cu(OTf)(2)-catalyzed aza-Friedel-Crafts reaction of o-arylated N-tosylbenzaldimines in high yields. This is an efficient, atom-economic, and green method. (C) 2010 Elsevier Ltd. All rights reserved.