2',3'-(isopropylidene)-5'-(phosphocholine)-adenosine | 849632-45-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 2',3'-(isopropylidene)-5'-(phosphocholine)-adenosine
• 英文别名: [(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 849632-45-7
• 化学式: C₁₈H₂₉N₆O₇P
• 分子量: 472.438
• InChiKey: XOAQBYFYSHLXIF-LSCFUAHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.03
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  155.9
• 氢给体数：
  1.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  2',3'-(isopropylidene)-5'-(phosphocholine)-adenosine 在 对甲苯磺酸 、 N,N'-羰基二咪唑 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 bis-(2',3'-oleoyl)-5'-(phosphocholine)-adenosine tosylate salt
  参考文献：
  名称：

  Vesicle formation from a synthetic adenosine based lipid

  摘要：

  We report the synthesis of a novel purine based amphiphile; di-oleyladenosinephospliocholine (DOAPC). Light microscopy, TEM and QELS studies on DOAPC in aqueous media Support the formation of lamellar systems. These investigations indicate that the presence of adenine does not prohibit the formation of lamellar organizations. Stable small unilamellar vesicles can be prepared by using extrusion techniques. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.095
• 作为产物：
  描述：

  2',3'-异丙叉腺苷 以 四氢呋喃 、 乙腈 为溶剂， 反应 39.0h， 生成 2',3'-(isopropylidene)-5'-(phosphocholine)-adenosine
  参考文献：
  名称：

  Vesicle formation from a synthetic adenosine based lipid

  摘要：

  We report the synthesis of a novel purine based amphiphile; di-oleyladenosinephospliocholine (DOAPC). Light microscopy, TEM and QELS studies on DOAPC in aqueous media Support the formation of lamellar systems. These investigations indicate that the presence of adenine does not prohibit the formation of lamellar organizations. Stable small unilamellar vesicles can be prepared by using extrusion techniques. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.095