1-cyclopropyl-1H-indazol-3-amine | 1242152-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-cyclopropyl-1H-indazol-3-amine
• 英文别名: 1-Cyclopropylindazol-3-amine
• CAS: 1242152-53-9
• 化学式: C₁₀H₁₁N₃
• 分子量: 173.217
• InChiKey: JDXFAUMXVDRFMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-cyclopropyl-1H-indazol-3-amine 在 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 1-[(1-Cyclopropylindazol-3-yl)-prop-2-ynoylamino]cyclopentane-1-carboxamide
  参考文献：
  名称：

  [EN] GPX4 INHIBITORS AND USE THEREOF
  [FR] INHIBITEURS DE GPX4 ET LEUR UTILISATION

  摘要：

  The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, specifically in treating cancer or autoimmune diseases. This disclosure also features a composition containing the same as well as methods of using and making the same.

  公开号：

  WO2024030651A1
• 作为产物：
  描述：

  2-溴-N-羟基苯甲酰胺 在 sodium methylate 、 copper diacetate 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基乙酰胺 为溶剂， 反应 4.0h， 生成 1-cyclopropyl-1H-indazol-3-amine
  参考文献：
  名称：

  [EN] GPX4 INHIBITORS AND USE THEREOF
  [FR] INHIBITEURS DE GPX4 ET LEUR UTILISATION

  摘要：

  The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, specifically in treating cancer or autoimmune diseases. This disclosure also features a composition containing the same as well as methods of using and making the same.

  公开号：

  WO2024030651A1

文献信息

• [EN] PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE<br/>[FR] DÉRIVÉ DE PYRIMIDO-PYRIMIDO-INDAZOLE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010098367A1

  公开（公告）日：2010-09-02

  The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a):; R1 means a -(C=O)aOb(C1-C6)alkyl group, a -(C=O)aOb(C2-C6)alkenyl group, a -(C=O)aOb(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; R2 and R3 each mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a -(C=O)aOb(C1-C6)alkyl group or a group of -(C=O)aN(R1e)R2e; R4 means a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments.

  这项发明是为了提供一种新型的抗癌药物或增敏剂，用于癌症化疗或放疗。通式(I)的化合物：其中A表示芳基或杂环基，或者是式(a)的基团；R1表示-(C=O)aOb(C1-C6)烷基、-(C=O)aOb(C2-C6)烯基、-(C=O)aOb(C3-C6)环烷基、芳基或杂环基；R2和R3各自表示氢原子、卤素原子、羟基、羧基、-(C=O)aOb(C1-C6)烷基或-(C=O)aN(R1e)R2e的基团；R4表示氢原子或(C1-C6)烷基等，具有优异的Wee1激酶抑制作用，因此在医学领域特别是各种癌症治疗领域中非常有用。
• PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE
  申请人：Goto Yasuhiro

  公开号：US20120134955A1

  公开（公告）日：2012-05-31

  The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a):; R 1 means a —(C═O) a O b (C1-C6)alkyl group, a —(C═O) a O b (C2-C6)alkenyl group, a —(C═O) a O b (C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; R 2 and R 3 each mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a —(C═O) a O b (C1-C6)alkyl group or a group of —(C═O) a N(R 1e )R 2e ; R 4 means a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee 1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments.

  本发明提供一种新型的抗癌剂或增敏剂，用于癌症化疗或放疗。该化合物的一般式（I）如下：其中，A表示芳基或杂环基，或式（a）的基团；R1表示—（C═O）aOb（C1-C6）烷基，—（C═O）aOb（C2-C6）烯基，—（C═O）aOb（C3-C6）环烷基，芳基或杂环基；R2和R3各表示氢原子、卤素原子、羟基、羧基、—（C═O）aOb（C1-C6）烷基或—（C═O）aN（R1e）R2e基团；R4表示氢原子或（C1-C6）烷基等。该化合物具有出色的Wee 1-激酶抑制作用，因此在医学领域，特别是各种癌症治疗领域中非常有用。
• US8288396B2
  申请人：——

  公开号：US8288396B2

  公开（公告）日：2012-10-16