6-bromo-13-chloro-2-[4-[(3S)-3-(2-methoxyethyl)piperazin-1-yl]piperidin-1-yl]-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene | 723300-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并环庚烷吡啶
• 英文名称: 6-bromo-13-chloro-2-[4-[(3S)-3-(2-methoxyethyl)piperazin-1-yl]piperidin-1-yl]-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
• CAS: 723300-62-7
• 化学式: C₂₆H₃₄BrClN₄O
• 分子量: 533.939
• InChiKey: ZEUKQLPASSHPQG-CHQVSRGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  40.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES
  申请人：Schering Corporation

  公开号：EP1572299B1

  公开（公告）日：2008-09-24
• 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES
  申请人：Guzi J. Timothy

  公开号：US20080004248A1

  公开（公告）日：2008-01-03

  In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17β-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.
• US7271175B2
  申请人：——

  公开号：US7271175B2

  公开（公告）日：2007-09-18
• US7485645B2
  申请人：——

  公开号：US7485645B2

  公开（公告）日：2009-02-03