| 1609388-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• CAS: 1609388-05-7
• 化学式: C₁₈H₂₃NO₈
• 分子量: 381.383
• InChiKey: FKUQFTDAPQKBBT-RDTXWAMCSA-N

物化性质

• 沸点：
  478.7±55.0 °C(predicted)
• 密度：
  1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  二碳酸二叔丁酯 、 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis

  摘要：

  The development of efficient and enantioselective intramolecular aza-spiroannulation onto benzofurans using chiral rhodium catalysis is described. The optimized reaction conditions [Rh-2(S-TCPTAD)(4) (3 mol %), PhIO (1.6 equiv), MeOH (10 equiv) in PhCF3, 0 degrees C] brought about oxidative aza-spiroannulation of 3-(carbamoylmethyl)benzofuran (3) resulting in (2R,3S)-2-methoxy-2H-spiro-[benzofuran-3,4'-oxazolidin]-2'-one (15a) in 69% yield with 86% ee, the absolute structure of which was determined by a combination of X-ray crystallography and vibrational circular dichroism (VCD) spectroscopy. The reaction is applicable to the asymmetric construction of various 2,3-dihydrobenzofuran derivatives bearing a nitrogen-containing tetrasubstituted carbon stereocenter at C3 (up to 92% ee).

  DOI：

  10.3987/com-14-12941