1,4-Bis-bromomethyl-2-dodecyloxy-benzene | 259217-14-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-Bis-bromomethyl-2-dodecyloxy-benzene
• CAS: 259217-14-6
• 化学式: C₂₀H₃₂Br₂O
• 分子量: 448.281
• InChiKey: DDJSFRQMMSORRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.78
• 重原子数：
  23.0
• 可旋转键数：
  14.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  四氢噻吩 、 1,4-Bis-bromomethyl-2-dodecyloxy-benzene 以 甲醇 为溶剂， 反应 20.0h， 生成 2-Dodecyloxy-1,4-phenylene dimethylene bis(tetrahydrothiophenium bromide)
  参考文献：
  名称：

  Optical Third Harmonic Generation of Poly(2-Alkoxy-1,4-Phenylenevinylene)'S

  摘要：

  A series of poly (2-alkoxy-1,4-phenylenevinylene)'s was synthesized by water-soluble precursor method. In this paper, three poly(1,4-phenylenevinylene) (PPV) derivatives were included, poly (2-methoxy-1,4-phenylenevinylene), poly(2-butoxy-1,4-phenylenevinylene) and poly (2-dodecyloxy-1,4-phenylenevinylene). These polymers were characterized using UV-visible, FT-IR spectroscopy and DSC, TGA thermal analyzer. The third order nonlinear optical susceptibilities of the polymers were determined using third harmonic generation (THG) method at 1907 nm, fundamental wavelength. Measured chi((3)) values are 10(-11) similar to 10(-12) esu order and as the side chain length is increased, the chi((3)) value is decreased because of the side chain effect on conjugation and of volume fraction.

  DOI：

  10.1080/10587259408039197
• 作为产物：
  描述：

  溴代十二烷 在 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 乙腈 为溶剂， 反应 48.0h， 生成 1,4-Bis-bromomethyl-2-dodecyloxy-benzene
  参考文献：
  名称：

  Bicephalic amphiphile architecture affects antibacterial activity

  摘要：

  A series of cationic amphiphiles, each with an aromatic core, was prepared and investigated for antimicrobial properties. The synthesized amphiphiles in this study are bicephalic (double-headed) in that they each possess two trimethylammonium head groups and a single linear alkoxy tail. Minimum inhibitory and minimum bactericidal concentrations of these amphiphiles were in the low micromolar range. Antimicrobial activities are highly sensitive to the chain length of the hydrophobic region, and modestly reliant on the relative positioning of the head groups on the aromatic core. These trends were more pronounced in time kill assays, wherein longer chain compounds required significantly shorter times to completely kill bacteria. Microscopy suggested that the mode of cell death was lysis. Strong inhibition was observed with both biscationic compounds and monocationic comparisons against Gram-positive bacteria: only biscationic amphiphiles maintained good activity versus the Gram-negative bacteria tested. These observations provide direction for future antimicrobial structural investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.06.026