| 1419557-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• CAS: 1419557-74-6
• 化学式: C₁₈H₁₉N₃O₃
• 分子量: 325.367
• InChiKey: MLYMDNYCOJTLEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  87.3
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  5-甲基靛红 、 5,5-二甲基-1,3-环己二酮 、 尿素 在 β-环糊精 作用下， 以 水 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  A new eco-friendly strategy for the synthesis of novel antimicrobial spiro-oxindole derivatives via supramolecular catalysis

  摘要：

  Novel spiro-oxindole derivatives were synthesised by one-pot multicomponent reaction using isatins, urea and 1,3-dicarbonyls. -Cyclodextrin, an oligosaccharide, catalysed the reaction and can be reused for further reaction after recovery. This developed synthetic route is environmentally benign in which water is used as solvent to produce excellent yields of products. The synthesised compounds were evaluated for their antimicrobial activities against two bacteria and two fungi. All the synthesised spiro-oxindoles exhibit significant antimicrobial activity.

  DOI：

  10.1080/10610278.2012.761341