| 1620634-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1620634-30-1
• 化学式: C₁₈H₂₃O₅P
• 分子量: 350.351
• InChiKey: OCYMLIRTLDGKST-GOSISDBHSA-N

物化性质

• 沸点：
  486.1±38.0 °C(predicted)
• 密度：
  1.181±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  diethyl (2-hydroxy-2-(naphthalen-2-yl)ethyl)phosphonate 、 乙酸酐 在 (((CH₃)2N)(CCHCHN)(C₅H₃))Fe(C₅(C₆H₅)5) 作用下， 以 2-甲基-2-丁醇 为溶剂， 反应 4.0h， 以55%的产率得到
  参考文献：
  名称：

  Kinetic resolution of 2-hydroxy-2-aryl-ethylphosphonates by a non-enzymatic acylation catalyst

  摘要：

  Optically pure hydroxyphosphonates are widely used as derivatizable compounds that can be incorporated into a variety of synthetic strategies for the preparation of other high value organic products. A non-enzymatic kinetic resolution procedure to obtain chiral 2-hydroxy-2-arylethylphosphonates from the easily available racemic counterparts is described. A range of 2-hydroxy-2-arylethylphosphonates was efficiently resolved employing a planar-chiral DMAP derived catalyst with good selectivities (up to S=68). The chiral hydroxyphosphonates were isolated in good yields and high enantiomeric excess (>94% ee). (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.102