4-t-Butylamino-2-butanol | 55423-37-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-t-Butylamino-2-butanol
• 英文别名: 4-(Tert-butylamino)butan-2-ol
• CAS: 55423-37-5
• 化学式: C₈H₁₉NO
• 分子量: 145.245
• InChiKey: OLYZHXWTZSSFQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丁烯酮 、 叔丁胺 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 4-t-Butylamino-2-butanol
  参考文献：
  名称：

  A Simplified Synthesis ofN-Substituted Azetidines

  摘要：

  DOI：

  10.1055/s-1974-23474

文献信息

• 10a-Azalide Compound
  申请人：Sugimoto Tomohiro

  公开号：US20090281292A1

  公开（公告）日：2009-11-12

  [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. [Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.

  【目标】提供一种具有新结构的化合物，对流感嗜血杆菌和红霉素耐药菌（例如耐药肺炎球菌和链球菌）以及传统的红霉素敏感菌具有有效作用。 【解决方案】本发明提供了一种新型10a-氮杂环十六元化合物，其化学式为（I），其药学上可接受的盐或其溶剂化物，或其制备的中间体。该化合物对流感嗜血杆菌、红霉素耐药性肺炎球菌等具有卓越的抗菌活性，因此可以作为治疗传染病的药物。
• Inhibition of OLIG2 activity
  申请人：CURTANA PHARMACEUTICALS, INC.

  公开号：US11242323B2

  公开（公告）日：2022-02-08

  Described herein are urea compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

  本文描述了抑制 Olig2 活性的脲化合物和含有此类化合物的药物组合物。本文还描述了使用此类 Olig2 抑制剂单独或与其他化合物联合治疗癌症和其他疾病的方法。特别是 Olig2 抑制剂可用于治疗胶质母细胞瘤。
• THIAZOLYL- OR THIADIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20180072712A1

  公开（公告）日：2018-03-15

  Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R 7 , are useful as kinase modulators, including IRAK-4 modulation.
• INHIBITION OF OLIG2 ACTIVITY
  申请人：Curtana Pharmaceuticals, Inc.

  公开号：US20200407329A1

  公开（公告）日：2020-12-31

  Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.
• ANALOGUES OF PARATHYROID HORMONE (1-34) THAT FUNCTION AS AGONISTS OF THE PARATHYROID HORMONE RECEPTOR-1 AND DISPLAY MODIFIED ACTIVITY PROFILES
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20200354428A9

  公开（公告）日：2020-11-12

  Described are polypeptide analogs of parathyroid hormone (PTH) that include an unnatural amino acid substitution at positions 7 or 8 from the N-terminus of the polypeptide. Also described are pharmaceutical compositions useful for treating hypoparathyroidism that contain the analogs and methods of using the analogs to treat hypoparathyroidism.