N'-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-yl-N,N-diethylpropane-1,3-diamine | 1246546-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: N'-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-yl-N,N-diethylpropane-1,3-diamine
• 英文别名: N',N'-diethyl-N-(3,5,11,14,16-pentazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),2,4,6,8(13),9,11,16,18-nonaen-4-yl)propane-1,3-diamine
• CAS: 1246546-84-8
• 化学式: C₂₁H₂₅N₇
• 分子量: 375.476
• InChiKey: FQGMFTZTIQHMKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS
  申请人：Tandon Manish

  公开号：US20100249108A1

  公开（公告）日：2010-09-30

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物以及合成这些化合物的方法。本发明还涉及含有取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物的药物组合物，并通过将这些化合物和药物组合物给予需要的受体中，治疗细胞增殖性疾病，如癌症的方法。
• US8349827B2
  申请人：——

  公开号：US8349827B2

  公开（公告）日：2013-01-08
• [EN] SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS<br/>[FR] COMPOSÉS DIPYRIDO-PYRIMIDO-DIAZÉPINE ET BENZO-PYRIDO-PYRIMIDO SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2010114898A1

  公开（公告）日：2010-10-07

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds of formula (I), substituted benzo-pyrido-pyrimido-diazepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.