| 1605332-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• CAS: 1605332-56-6
• 化学式: C₉H₁₀O₅
• 分子量: 198.175
• InChiKey: MBDHLKULRKPQPK-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  丁香醛 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  A Practical and Economical High-Yielding, Six-Step Sequence Synthesis of a Flavone: Application to the Multigram-Scale Synthesis of Ladanein

  摘要：

  Herein we report a short and economic synthesis of the antiviral flavonoid lead ladanein (1). Ladanein is obtained from 2,6-dimethoxyquinone (11) in six steps with 51% overall yield. After a high-yielding reductive acetylation and Fries rearrangement, the flavone skeleton is built by means of a Baker-Venkataraman rearrangement. Throughout the synthetic pathway no chromatographic columns were used, and the reaction products were isolated and purified by optimized work-up and crystallization processes. This new process has been tested on a multigram-scale with an improved overall yield from 16 to 51% through six steps, and three chromatographic purifications used in the earlier synthesis were eliminated.

  DOI：

  10.1021/op4003642