7-Azido-2,3,6,7-tetrahydro-furo[2,3-g]chromen-8-one | 174637-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-Azido-2,3,6,7-tetrahydro-furo[2,3-g]chromen-8-one
• CAS: 174637-12-8
• 化学式: C₁₁H₉N₃O₃
• 分子量: 231.211
• InChiKey: CZQBZAYCLSAOLG-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  7-Azido-2,3,6,7-tetrahydro-furo[2,3-g]chromen-8-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 N-((7R,8S)-8-Hydroxy-3,6,7,8-tetrahydro-2H-furo[2,3-g]chromen-7-yl)-propionamide
  参考文献：
  名称：

  Tetracyclic analogues of [+]-S 14297: Synthesis and determination of affinity and selectivity at cloned human dopamine D3 vs D2 receptors

  摘要：

  Starting from the structure of the preferential D-3 antagonist S 14297 (1), we have prepared a series of cis and trans tetracyclic derivatives of general formula I in order to improve potency and selectivity for D-3 receptors. The trans oxazino derivative 2c, showed slightly increased affinity at D-3 receptors and double the selectivity for D-3 over D-2 receptors, in comparison to S 14297. Cis derivatives and compounds where R-1 is aralkyl were totally devoid of activity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00126-1
• 作为产物：
  描述：

  7-Bromo-2,3,6,7-tetrahydro-furo[2,3-g]chromen-8-one 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以94%的产率得到7-Azido-2,3,6,7-tetrahydro-furo[2,3-g]chromen-8-one
  参考文献：
  名称：

  Tetracyclic analogues of [+]-S 14297: Synthesis and determination of affinity and selectivity at cloned human dopamine D3 vs D2 receptors

  摘要：

  Starting from the structure of the preferential D-3 antagonist S 14297 (1), we have prepared a series of cis and trans tetracyclic derivatives of general formula I in order to improve potency and selectivity for D-3 receptors. The trans oxazino derivative 2c, showed slightly increased affinity at D-3 receptors and double the selectivity for D-3 over D-2 receptors, in comparison to S 14297. Cis derivatives and compounds where R-1 is aralkyl were totally devoid of activity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00126-1