7N,12N-dimethyldehydroaspidostomide D | 1609960-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7N,12N-dimethyldehydroaspidostomide D
• CAS: 1609960-21-5
• 化学式: C₁₇H₁₀Br₅N₃O
• 分子量: 671.806
• InChiKey: PUQKHQHDORHGNU-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  aspidostomide D 、 碘甲烷 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.33h， 以60%的产率得到7N,12N-dimethyldehydroaspidostomide D
  参考文献：
  名称：

  Bromopyrrole Alkaloids Isolated from the Patagonian Bryozoan Aspidostoma giganteum

  摘要：

  Nine new bromopyrrole alkaloids, aspidostomides A-H and aspidazide A (1-9), were isolated from the Patagonian bryozoan Aspidostoma giganteum. Aspidostomides A-H have dibromotyrosine- or bromotryptophan-derived moieties forming either linear amides or pyrroloketopiperazine-type lactams with a bromopyrrole carboxylic acid as a common structural motif. On the other hand, aspidazide A is a rare asymmetric acyl azide formed by an N-N link of two different pyrroloketopiperazine lactams and is the first isolated compound of this class from marine invertebrates. This work is the first report of secondary metabolites isolated from a bryozoan from the Patagonian region. The structures of compounds 1-9 were elucidated by spectroscopic methods and chemical transformations. One of these compounds, aspidostomide E (5), was moderately active against the 786-O renal carcinoma cell line.

  DOI：

  10.1021/np500012y