6-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | 40000-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 6-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
• 英文别名: 6-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
• CAS: 40000-92-8
• 化学式: C₈H₇N₃O
• 分子量: 161.163
• InChiKey: UYKUJJLUUABHSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHODS AND COMPOSITIONS FOR MODULATING SPLICING
  申请人：Skyhawk Therapeutics, Inc.

  公开号：US20220048890A1

  公开（公告）日：2022-02-17

  Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
• [EN] NEW CHEMICAL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS CHIMIQUES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010007114A2

  公开（公告）日：2010-01-21

  The present invention encompasses compounds of general formula (1) wherein the units W, A, L, Qa and QH are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.