2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin 2-yl]-N-[(1S)-indan-1-yl]-acetamide | 361386-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin 2-yl]-N-[(1S)-indan-1-yl]-acetamide
• 英文别名: 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide；N-[(1S)-2,3-dihydro-1H-inden-1-yl]-2-[(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]acetamide
• CAS: 361386-74-5
• 化学式: C₃₁H₃₆N₂O₅
• 分子量: 516.637
• InChiKey: SGHBDLOMRUXKQF-UIOOFZCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  S-四氢罂粟碱 、 溴乙酰溴 、 (S)-(+)-1-氨基茚满 生成 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin 2-yl]-N-[(1S)-indan-1-yl]-acetamide
  参考文献：
  名称：

  1,2,3,4-tetrahydroisoquinoline derivatives

  摘要：

  本发明涉及一种新型1,2,3,4-四氢异喹啉衍生物(I式)及其在制备药物组分中作为活性成分的用途。本发明还涉及相关方面，包括制备该化合物的过程、含有其中一种或多种化合物的药物组合物，特别是它们作为促进睡眠激素受体拮抗剂的用途。

  公开号：

  US06703392B2

文献信息

• Tetrahydroisoquinoline Derivatives to Enhance Memory Function
  申请人：Jenck Francois

  公开号：US20090082394A1

  公开（公告）日：2009-03-26

  The invention relates to the use of tetrahydroisoquinoline derivatives for the preparation of a medicament to enhance, maintain and/or restore all stages and/or types of short-, middle- and/or long-term memory.

  该发明涉及使用四氢异喹啉衍生物制备一种药物，用于增强、维持和/或恢复所有阶段和/或类型的短期、中期和/或长期记忆。
• Methods and pharmaceutical compositions for the treatment of cancer
  申请人：INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

  公开号：US10894042B2

  公开（公告）日：2021-01-19

  The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. More particularly, the present invention relates to a method of treating cancer in subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one OX1R antagonist.

  本发明涉及治疗癌症的方法和药物组合物。更具体地说，本发明涉及一种治疗有需要的受试者癌症的方法，该方法包括向受试者施用治疗有效量的至少一种 OX1R 拮抗剂。
• USE OF OX1R ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
  申请人：Inserm (Institut National De La Sante et de la Recherche Medicale)

  公开号：US20190083508A1

  公开（公告）日：2019-03-21

  The present invention relates to methods and pharmaceutical compositions for the treatment of inflammatory bowel diseases.
• METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATORY
  申请人：INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCJAE MÉDICALE

  公开号：US20190151304A1

  公开（公告）日：2019-05-23

  The present invention relates to methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases. The inventors showed that orexin receptor antagonists have anti-inflammatory properties. Indeed, these compounds are antagonist for OX1R-mediated calcium mobilization but a full agonist for OX1R-mediated mitochondrial apoptosis, which is the mechanism involved in the improvement of resolution of inflammation observed in the models of colitis, multiple sclerosis and pancreatitis. In particular, the present invention relates to a method of treating an autoimmune inflammatory disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of at least one OX1R antagonist.
• US6703392B2
  申请人：——

  公开号：US6703392B2

  公开（公告）日：2004-03-09