(9-benzyl-2-chloro-9H-purin-6-yl)-(4-chloro-phenyl)-amine | 1062607-66-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (9-benzyl-2-chloro-9H-purin-6-yl)-(4-chloro-phenyl)-amine
• 英文别名: 9-benzyl-2-chloro-N-(4-chlorophenyl)purin-6-amine
• CAS: 1062607-66-2
• 化学式: C₁₈H₁₃Cl₂N₅
• 分子量: 370.241
• InChiKey: CWIBBYFLONRSHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
  申请人：Eriksen Birgitte L.

  公开号：US20100120797A1

  公开（公告）日：2010-05-13

  This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

  本发明涉及新型嘌呤衍生物及其用作钾通道调节剂的用途。此外，本发明还涉及用于治疗或缓解与钾通道活性相关的疾病或障碍的药物组合物。
• Purinyl derivatives and their use as potassium channel modulators
  申请人：NeuroSearch A/S

  公开号：EP2402341A2

  公开（公告）日：2012-01-04

  This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

  本发明涉及新型嘌呤基衍生物及其作为钾通道调节剂的用途。此外，本发明还涉及用于治疗或缓解与钾通道活性有关的疾病或紊乱的药物组合物。
• US8362024B2
  申请人：——

  公开号：US8362024B2

  公开（公告）日：2013-01-29
• US9340544B2
  申请人：——

  公开号：US9340544B2

  公开（公告）日：2016-05-17
• [EN] PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS<br/>[FR] DÉRIVÉS DE PURINYLE ET LEUR UTILISATION EN TANT QUE MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2008116911A1

  公开（公告）日：2008-10-02

  [EN] This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
  [FR] L'invention concerne des nouveaux dérivés de purinyle et leur utilisation en tant qu'agents modulateurs des canaux potassiques. L'invention concerne également des compositions pharmaceutiques à utiliser pour traiter ou soulager des maladies ou des troubles associés à l'activité des canaux potassiques.