1-[1-(4-Methoxyphenyl)-4-pyrrolidin-1-ylnaphthalen-2-yl]pyrrolidine | 1328882-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[1-(4-Methoxyphenyl)-4-pyrrolidin-1-ylnaphthalen-2-yl]pyrrolidine
• 英文别名: 1-[1-(4-methoxyphenyl)-4-pyrrolidin-1-ylnaphthalen-2-yl]pyrrolidine
• CAS: 1328882-66-1
• 化学式: C₂₅H₂₈N₂O
• 分子量: 372.51
• InChiKey: VGARFNBUYBUPBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 1-methoxy-4-(phenylbuta-1,3-diynyl)benzene 在 copper(l) chloride 作用下， 反应 36.0h， 生成 1-(6-Methoxy-4-phenyl-3-pyrrolidin-1-ylnaphthalen-1-yl)pyrrolidine 、 1-[1-(4-Methoxyphenyl)-4-pyrrolidin-1-ylnaphthalen-2-yl]pyrrolidine
  参考文献：
  名称：

  Copper(I)-catalyzed reaction of diaryl buta-1,3-diynes with cyclic amines: an atom-economic approach to amino-substituted naphthalene derivatives

  摘要：

  1,4-Diaryl-1,3-butadiynes react with cyclic amines, such as pyrrolidine, piperidine, and morpholine in the presence of a catalytic amount of CuCl to afford amino-substituted naphthalene derivatives with good to high yields. The new catalytic procedure provides an atom-economic, one-pot synthetic method for the synthesis of naphthalene derivatives from easily available 1,4-diaryl-1,3-butadiynes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.046

文献信息

• Copper(I)-catalyzed reaction of diaryl buta-1,3-diynes with cyclic amines: an atom-economic approach to amino-substituted naphthalene derivatives
  作者：Hongbin Sun、Xiaoli Wu、Ruimao Hua

  DOI：10.1016/j.tetlet.2011.06.046

  日期：2011.8

  1,4-Diaryl-1,3-butadiynes react with cyclic amines, such as pyrrolidine, piperidine, and morpholine in the presence of a catalytic amount of CuCl to afford amino-substituted naphthalene derivatives with good to high yields. The new catalytic procedure provides an atom-economic, one-pot synthetic method for the synthesis of naphthalene derivatives from easily available 1,4-diaryl-1,3-butadiynes. (C) 2011 Elsevier Ltd. All rights reserved.