Proceragenin | 144334-40-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Proceragenin
• 英文别名: (5I+/-,7I(2))-7,14-Dihydroxycard-20(22)-enolide；3-[(5R,7S,8S,9S,10S,13R,14S,17R)-7,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
• CAS: 144334-40-7
• 化学式: C₂₃H₃₄O₄
• 分子量: 374.521
• InChiKey: ZYEOCZJSKXSFRT-MMBQXPGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Proceragenin 在 jones reagent 作用下， 以 丙酮 为溶剂， 以2.5 mg的产率得到4-((5R,8R,9S,10S,13R,14S,17R)-14-Hydroxy-10,13-dimethyl-7-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one
  参考文献：
  名称：

  Proceragenin, an antibacterial cardenolide from Calotropis procera

  摘要：

  A new cardenolide, proceragenin, has been isolated from Calotropis procera. Its structure was determined as 7-beta,14-beta-dihydroxy-5-alpha-card-20(22)-enolide through spectroscopic studies including 2D NMR and NOE difference measurement. Its biological screening showed antibacterial activity against both Gram positive and Gram negative bacteria.

  DOI：

  10.1016/0031-9422(92)83639-g

文献信息

• Proceragenin, an antibacterial cardenolide from Calotropis procera
  作者：Nargis Akhtar、Abdul Malik、Samina Noor Ali、Shahana Urooj Kazmit

  DOI：10.1016/0031-9422(92)83639-g

  日期：1992.8

  A new cardenolide, proceragenin, has been isolated from Calotropis procera. Its structure was determined as 7-beta,14-beta-dihydroxy-5-alpha-card-20(22)-enolide through spectroscopic studies including 2D NMR and NOE difference measurement. Its biological screening showed antibacterial activity against both Gram positive and Gram negative bacteria.