N-(8-Oxo-3,6,7,8-tetrahydro-2H-furo[2,3-g]chromen-7-yl)-propionamide | 174637-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-(8-Oxo-3,6,7,8-tetrahydro-2H-furo[2,3-g]chromen-7-yl)-propionamide
• CAS: 174637-30-0
• 化学式: C₁₄H₁₅NO₄
• 分子量: 261.277
• InChiKey: LHFWNRXCNMTJKG-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  N-(8-Oxo-3,6,7,8-tetrahydro-2H-furo[2,3-g]chromen-7-yl)-propionamide 在 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 sodium hydride 、 sodium carbonate 作用下， 以 四氢呋喃 、 乙醇 、 水 、 乙酸乙酯 、 乙腈 为溶剂， 生成 (4aS,11bS)-4-Propyl-3,4,4a,8,9,11b-hexahydro-2H,5H-1,6,10-trioxa-4-aza-cyclopenta[b]phenanthrene
  参考文献：
  名称：

  Tetracyclic analogues of [+]-S 14297: Synthesis and determination of affinity and selectivity at cloned human dopamine D3 vs D2 receptors

  摘要：

  Starting from the structure of the preferential D-3 antagonist S 14297 (1), we have prepared a series of cis and trans tetracyclic derivatives of general formula I in order to improve potency and selectivity for D-3 receptors. The trans oxazino derivative 2c, showed slightly increased affinity at D-3 receptors and double the selectivity for D-3 over D-2 receptors, in comparison to S 14297. Cis derivatives and compounds where R-1 is aralkyl were totally devoid of activity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00126-1
• 作为产物：
  描述：

  丙酰氯 、 7-Amino-2,3,6,7-tetrahydro-furo[2,3-g]chromen-8-one 在 sodium carbonate 作用下， 以 水 、 乙酸乙酯 为溶剂， 以93%的产率得到N-(8-Oxo-3,6,7,8-tetrahydro-2H-furo[2,3-g]chromen-7-yl)-propionamide
  参考文献：
  名称：

  Tetracyclic analogues of [+]-S 14297: Synthesis and determination of affinity and selectivity at cloned human dopamine D3 vs D2 receptors

  摘要：

  Starting from the structure of the preferential D-3 antagonist S 14297 (1), we have prepared a series of cis and trans tetracyclic derivatives of general formula I in order to improve potency and selectivity for D-3 receptors. The trans oxazino derivative 2c, showed slightly increased affinity at D-3 receptors and double the selectivity for D-3 over D-2 receptors, in comparison to S 14297. Cis derivatives and compounds where R-1 is aralkyl were totally devoid of activity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00126-1