3-(6-Azidohexyl)-2-[3-(1-ethyl-3,3-dimethylindol-2-ylidene)prop-1-enyl]-1,1-dimethylbenzo[e]indol-3-ium | 1415633-19-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(6-Azidohexyl)-2-[3-(1-ethyl-3,3-dimethylindol-2-ylidene)prop-1-enyl]-1,1-dimethylbenzo[e]indol-3-ium
• 英文别名: 3-(6-azidohexyl)-2-[3-(1-ethyl-3,3-dimethylindol-2-ylidene)prop-1-enyl]-1,1-dimethylbenzo[e]indol-3-ium
• CAS: 1415633-19-0
• 化学式: C₃₅H₄₂N₅
• 分子量: 532.752
• InChiKey: OWBZSECLQVEREM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,1,2-trimethyl-3-(6-azidohexyl)-1H-benzo[e]indolium bromide 、 2-(2-anilinovinyl)-1-ethyl-3,3-dimethyl-3H-indolium iodide 在 吡啶 、 乙酸酐 作用下， 反应 10.5h， 以28%的产率得到3-(6-Azidohexyl)-2-[3-(1-ethyl-3,3-dimethylindol-2-ylidene)prop-1-enyl]-1,1-dimethylbenzo[e]indol-3-ium
  参考文献：
  名称：

  One pot conjugation of small molecules to RNA using click chemistry

  摘要：

  A convenient, one step conjugation method based on click chemistry has been developed for creating new RNA conjugates. The coupling reaction was performed in RNA 2'-hydroxy deprotection solution, with conjugation and TBDMS-deprotection being accomplished at the same time. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.128

文献信息

• One pot conjugation of small molecules to RNA using click chemistry
  作者：Wei Wang、Ke Chen、Dezhong Qu、Weilin Chi、Wei Xiong、Yanxiang Huang、Jian Wen、Shipeng Feng、Biliang Zhang

  DOI：10.1016/j.tetlet.2012.09.128

  日期：2012.12

  A convenient, one step conjugation method based on click chemistry has been developed for creating new RNA conjugates. The coupling reaction was performed in RNA 2'-hydroxy deprotection solution, with conjugation and TBDMS-deprotection being accomplished at the same time. (C) 2012 Elsevier Ltd. All rights reserved.