diethyl 3α-formyloxy-24-nor-5β-cholane-23-phosphonate | 623141-78-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: diethyl 3α-formyloxy-24-nor-5β-cholane-23-phosphonate
• CAS: 623141-78-6
• 化学式: C₂₈H₄₉O₅P
• 分子量: 496.668
• InChiKey: RBLZTJPHSSXBAZ-IOIYRQMXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.48
• 重原子数：
  34.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  diethyl 3α-formyloxy-24-nor-5β-cholane-23-phosphonate 在 碘代三甲硅烷 、 sodium hydroxide 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 28.0h， 以75%的产率得到3α-hydroxy-24-nor-5β-cholane-23-phosphonic acid
  参考文献：
  名称：

  First synthesis of phosphonobile acids and preliminary studies on their aggregation properties

  摘要：

  The synthesis of three novel phosphonobile acids from natural bile acids is reported. The CMC of phosphonodeoxycholic acid (PDCA) at pH 8.2 was found to be lower than that of the parent deoxycholic acid (DCA). PDCA micelles were also found to have higher microviscosity compared to DCA micelles, suggesting higher hydrophobicity and tighter packing in the interior of PDCA micelles. PDCA aggregated further to form an aqueous gel at pH 4. (C) 2003 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(03)00051-5
• 作为产物：
  描述：

  石胆酸 在 lead(IV) acetate 、 碘 作用下， 以 四氯化碳 为溶剂， 反应 27.0h， 生成 diethyl 3α-formyloxy-24-nor-5β-cholane-23-phosphonate
  参考文献：
  名称：

  Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids

  摘要：

  A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increase in the bulk pH. ((c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2005.03.008