| 137509-56-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 137509-56-9
• 化学式: C₃₀H₂₄FeN₂O₁₀*H₂O
• 分子量: 646.39
• InChiKey: ILIHEZPPPNPWBO-XOCLESOZSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-羟基-1-萘甲醛 在 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 反应 17.0h， 生成
  参考文献：
  名称：

  Synthesis, physicochemical studies, embryos toxicity and DNA interaction of some new Iron(II) Schiff base amino acid complexes

  摘要：

  New Fe(II) Schiff base amino acid complexes derived from the condensation of o-hydroxynaphthaldehyde with L-alanine, L-phenylalanine, L-aspartic acid, L-histidine and L-arginine were synthesized and characterized by elemental analysis, IR, electronic spectra, and conductance measurements. The stoichiometry and the stability constants of the complexes were determined spectrophotometrically. The investigated Schiff bases exhibited tridentate coordination mode with the general formulae [Fe(HL)(2)]center dot nH(2)O for all amino acids except L-histidine. But in case of L-histidine, the ligand acts as tetradentate ([FeL(H2O)(2)]center dot 2H(2)O), where HL = mono anion and L = dianion of the ligand. The structure of the prepared complexes is suggested to be octahedral. The prepared complexes were tested for their toxicity on chick embryos and found to be safe until a concentration of 100 mu g/egg with full embryos formation. The interaction between CF-DNA and the investigated complexes were followed by spectrophotometry and viscosity measurements. It was found that, the prepared complexes bind to DNA via classical intercalative mode and showed a different DNA cleavage activity with the sequence: nhi > nari > nali > nasi > nphali. The thermodynamic Profile of the binding of nphali complex and CF-DNA was constructed by analyzing the experimental data of absorption titration and UV melting studies with the McGhee equation, van't Hoff's equation, and the Gibbs-Helmholtz equation. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2013.02.023

文献信息

• Design, characterization, teratogenicity testing, antibacterial, antifungal and DNA interaction of few high spin Fe(II) Schiff base amino acid complexes
  作者：Laila H. Abdel-Rahman、Rafat M. El-Khatib、Lobna A.E. Nassr、Ahmed M. Abu-Dief、Fakhr El-Din Lashin

  DOI：10.1016/j.saa.2013.03.061

  日期：2013.7

  of the complexes were determined spectrophotometrically. Correlation of all spectroscopic data suggested that Schiff bases ligands exhibited tridentate with ONO sites coordinating to the metal ions via protonated phenolic-OH, azomethine-N and carboxylate-O with the general formulae [Fe(HL)2]·nH2O. But in case of l-histidine, the ligand acts as tetradentate via deprotonated phenolic-OH, azomethine-N,

  在这项研究中，合成了由邻羟基萘甲醛与1-丙氨酸，1-苯丙氨酸，1-天冬氨酸，1-组氨酸和1-精氨酸缩合而成的新的Fe（II）席夫碱氨基酸螯合物。热重分析，摩尔电导，红外，电子，质谱和磁矩测量。分光光度法测定了配合物的化学计量和稳定性常数。所有光谱数据的相关性表明，席夫碱配体表现出三齿形，其ONO位点通过具有通式[Fe（HL）2 ]·的质子化酚醛-OH，偶氮甲碱-N和羧酸酯-O与金属离子配位。Ñ ħ 2 O.但是，在的情况下，升-组氨酸，所述配体充当通过去质子化的酚OH，偶氮甲碱-N，羧酸盐的O和N的咪唑环（[FEL（H四齿2 O）2 ]·2H 2 ö ），其中HL =配体的单阴离子和L =二价阴离子。建议制备的配合物的结构为八面体。测试了制备的复合物的致畸性在雏鸡胚胎上使用，直到浓度达到100μg/蛋且完整的胚胎形成时才是安全的。此外，通过分光光度法和粘度测量来跟踪CT-DNA与所研究的复