methyl 3,8-dioxatricyclo[3.2.1.0(2,4)]octane-6-carboxylate | 827607-30-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: methyl 3,8-dioxatricyclo[3.2.1.0(2,4)]octane-6-carboxylate
• 英文别名: Methyl 3,8-dioxatricyclo[3.2.1.0,2,4]octane-6-carboxylate；methyl 3,8-dioxatricyclo[3.2.1.02,4]octane-6-carboxylate
• CAS: 827607-30-7
• 化学式: C₈H₁₀O₄
• mdl: MFCD00599873
• 分子量: 170.165
• InChiKey: OARAGBOCQAZZPY-UHFFFAOYSA-N

物化性质

• 沸点：
  237.0±30.0 °C(Predicted)
• 密度：
  1.375±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  48.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  rac-(1R,2S,4R,5S,6R)-6-methoxycarbonyl-3,8-dioxatricyclo[3.2.1.0^2,4]octane 在 pig liver esterase 作用下， 反应 24.0h， 生成 methyl 3,8-dioxatricyclo[3.2.1.0(2,4)]octane-6-carboxylate 、 2,3-epoxy-7-oxabicyclo[2.2.1]heptane-5-carboxylic acid
  参考文献：
  名称：

  Enzyme-catalyzed resolution of 3,8-dioxatricyclo[3.2.1.02,4]octane-6-carboxylic esters and the application to the synthesis of 3-epishikimic acid

  摘要：

  3,8-Dioxatricyclo[3 2 1 0(2 4)]octane-6-carboxylic acid, whose racemic form is readily available on a large scale, is a versatile starting material for the synthesis of carbasugars and carbocyclic biologically active natural products. In this study, the enzyme-catalyzed kinetic resolution was attempted on a variety of corresponding carboxylic esters. The hydrophobic and hydrophilic properties of ester substituents greatly affected the rate of reaction and the enantioselectivity. Hydrolysis of the corresponding 2'-chlotoethyl ester with pig liver esterase worked well in a highly enantioselective manner (E = 116) to give the hydiolyzate (90.6% ee) and unreacted ester recovery (99.4% ee). The hydrolyzate is a piecursor for (-)-oseltamivir phosphate, and a route to (3S,4S,5R)-(-)-3-epishikimic acid was developed from the recovered ester. (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2009.07.049

文献信息

• Novel compound, polymer, resist composition, and patterning process
  申请人：Hasegawa Koji

  公开号：US20050014092A1

  公开（公告）日：2005-01-20

  There is disclosed a polymer containing at least a repeating unit represented by the following general formula (1), and the resist composition containing the polymer as a base resin, especially a chemically amplified resist composition. There can be provided a resist composition which has etching resistance in a practical use level, and is excellent in an adhesion property with a substrate and an affinity with a developer, and has a sensitivity and resolving power which is far excellent compared with a conventional one, wherein swelling is small at the time of development, especially for photolithography which uses a high-energy beam as a light source, and especially be provided a chemically amplified resist composition.

  本发明公开了一种聚合物，其至少包含由下述通式（1）表示的重复单元，并且该聚合物作为基础树脂含于抗蚀剂组成物中，特别是化学增感抗蚀剂组成物中。本发明可提供一种在实际使用水平上具有蚀刻抗性、与基板具有优异的粘附性和与显影剂具有亲和性，并且具有远优于传统抗蚀剂的感度和分辨率的抗蚀剂组成物，在开发时膨胀小，特别适用于使用高能光束作为光源的光刻技术，特别是化学增感抗蚀剂组成物。
• ACTIVE ENERGY RAY-CURABLE COMPOSITION, ACTIVE ENERGY RAY-CURABLE INK COMPOSITION AND INKJET RECORDING METHOD
  申请人：KYOTA Hirokazu

  公开号：US20100247796A1

  公开（公告）日：2010-09-30

  The present invention provides an active energy ray-curable composition containing: a compound configured to generate an acid upon irradiation with active energy rays; and a cationic polymerizable monomer, the cationic polymerizable monomer containing a polyfunctional oxirane compound having, in a molecule, one bicyclo ring skeleton or tricyclo ring skeleton having at least one oxygen atom in the ring, provided that 3-membered rings and 4-membered rings containing oxygen atoms are not included in the ring structure of the bicyclo ring skeleton or tricyclo ring skeleton, and the polyfunctional oxirane compound carrying two or more oxirane rings.
• US7169541B2
  申请人：——

  公开号：US7169541B2

  公开（公告）日：2007-01-30