N-[1-({7-[(2-methoxyethoxy)methyl]naphthalen-2-yl}methyl)piperidin-4-yl]-9H-fluorene-9-carboxamide | 1018072-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-[1-({7-[(2-methoxyethoxy)methyl]naphthalen-2-yl}methyl)piperidin-4-yl]-9H-fluorene-9-carboxamide
• 英文别名: N-[1-[[7-(2-methoxyethoxymethyl)naphthalen-2-yl]methyl]piperidin-4-yl]-9H-fluorene-9-carboxamide
• CAS: 1018072-93-9
• 化学式: C₃₄H₃₆N₂O₃
• 分子量: 520.671
• InChiKey: URWZNASWJNWKBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE
  申请人：Sekiguchi Yoshinori

  公开号：US20100081825A1

  公开（公告）日：2010-04-01

  Disclosed is a pharmaceutical composition comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, which has an antagonistic activity on a melanin-concentrating hormone receptor. The pharmaceutical composition is useful, due to its antagonistic activity on a MCH receptor, for the prevention or treatment of a disease such as depression, anxiety disorders (e.g., generalized anxiety disorder, post traumatic stress disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder), attention deficit disorder, mania, manic-depressive disorder, schizophrenia, mood disorders, stress, sleep disorder, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, a cardiovascular diseases, hypertension, dyslipidemia, cardiac infarction, movement disorder (e.g., Parkinson's disease, epilepsy, convulsion, tremor), drug abuse and drug addiction.

  本发明揭示了一种药物组合物，其包括一种由式(I)表示的化合物或其药学上可接受的盐作为活性成分，该化合物具有对黑色素浓集激素受体的拮抗活性。该药物组合物由于其对MCH受体的拮抗活性，可用于预防或治疗抑郁症、焦虑障碍（例如广泛性焦虑症、创伤后应激障碍、恐慌症、强迫症、社交焦虑症）、注意力缺陷障碍、躁狂、躁郁症、精神分裂症、情绪障碍、压力、睡眠障碍、发作、记忆障碍、认知障碍、痴呆、健忘症、谵妄、肥胖症、进食障碍、食欲障碍、过度进食、暴食症、食物恐惧症、糖尿病、心血管疾病、高血压、脂质代谢异常、心肌梗塞、运动障碍（例如帕金森病、癫痫、抽搐、震颤）、药物滥用和药物成瘾等疾病的预防或治疗。