6,8-Bis(methoxymethoxy)-2,2-dimethylchromene | 1134100-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6,8-Bis(methoxymethoxy)-2,2-dimethylchromene
• 英文别名: 6,8-bis(methoxymethoxy)-2,2-dimethylchromene
• CAS: 1134100-11-0
• 化学式: C₁₅H₂₀O₅
• 分子量: 280.321
• InChiKey: GMLRMXBEIOIGJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6,8-Bis(methoxymethoxy)-2,2-dimethylchromene 、 1-溴-3-甲基-2-丁烯 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 2.25h， 以86%的产率得到6,8-Bis(methoxymethoxy)-2,2-dimethyl-7-(3-methylbut-2-enyl)chromene
  参考文献：
  名称：

  Total synthesis of tovophyllin B

  摘要：

  The first total synthesis of tovophyllin B (2), an antimicrobial xanthone derived from mangosteen. has been accomplished through a convergent strategy from building blocks 6 and 7 involving lithium-mediated coupling, dehydrative cyclization, and 6 pi electrocyclization as key steps. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.096
• 作为产物：
  描述：

  2,4-Bis(methoxymethoxy)-1-(2-methylbut-3-yn-2-yloxy)benzene 以 甲苯 为溶剂， 反应 48.0h， 生成 6,8-Bis(methoxymethoxy)-2,2-dimethylchromene
  参考文献：
  名称：

  Total synthesis of tovophyllin B

  摘要：

  The first total synthesis of tovophyllin B (2), an antimicrobial xanthone derived from mangosteen. has been accomplished through a convergent strategy from building blocks 6 and 7 involving lithium-mediated coupling, dehydrative cyclization, and 6 pi electrocyclization as key steps. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.096

文献信息

• Total synthesis of tovophyllin B
  作者：Valer Jeso、K.C. Nicolaou

  DOI：10.1016/j.tetlet.2008.12.096

  日期：2009.3

  The first total synthesis of tovophyllin B (2), an antimicrobial xanthone derived from mangosteen. has been accomplished through a convergent strategy from building blocks 6 and 7 involving lithium-mediated coupling, dehydrative cyclization, and 6 pi electrocyclization as key steps. (C) 2008 Elsevier Ltd. All rights reserved.