17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal | 64727-89-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal
• CAS: 64727-89-5
• 化学式: C₂₅H₃₆O₆
• 分子量: 432.557
• InChiKey: MDQRCGNSXZOCLB-FSNMPHKHSA-N

反应信息

• 作为反应物：
  描述：

  17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal 在 N-溴代丁二酰亚胺(NBS) 、 potassium acetate 作用下， 以 四氯化碳 为溶剂， 生成 7α-bromo-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal 、 7β-bromo-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal
  参考文献：
  名称：

  7α- and 7β-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol. Synthesis and immunogenic properties

  摘要：

  7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers were used for immunization. In both cases, highly specific antisera were obtained which may possibly be used to assay human plasma 17-hydroxyprogesterone and 11-deoxycortisol without chromatographic purification.

  DOI：

  10.1016/0039-128x(80)90112-9