1-[4-(2,3-dihydro-6-hydroxy)benzopyran]imido-3-(4-piperidine) butyl-2,4-imidazoledione | 1145670-86-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 1-[4-(2,3-dihydro-6-hydroxy)benzopyran]imido-3-(4-piperidine) butyl-2,4-imidazoledione
• 英文别名: 1-[(E)-(6-hydroxy-2,3-dihydrochromen-4-ylidene)amino]-3-(4-piperidin-1-ylbutyl)imidazolidine-2,4-dione
• CAS: 1145670-86-5
• 化学式: C₂₁H₂₈N₄O₄
• 分子量: 400.478
• InChiKey: CNWQVOHHHNIERX-RELWKKBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Chroman Compound, Processes for Its Preparation, and Its Pharmaceutical Use
  申请人：You Qidong

  公开号：US20080103307A1

  公开（公告）日：2008-05-01

  The present invention provided a chroman compound, the method of its preparation and pharmaceutical applications. The compound are represented by formula (I) and its pharmaceutical salt, where in :x is for O or S; n is for 2, 3 or 4; R 1 is 6-situ or 7-situ halogen, C 1-4 alkyl, C 1-4 alkyoxyl, benzyloxy, acylamino; R 2 is nitrogen-containing pentatomic or hexahydric substituted heterocyclic ring. The compound is useful to prepare anti-arrhythmic drugs, the reaction conditions of the method are mild, the raw material are plenty and easy to be obtained, and the operation and post-treatment are simple.

  本发明提供了一种色酮化合物、其制备方法和药物应用。该化合物由公式(I)及其药物盐表示，其中：x代表O或S；n代表2、3或4；R1为6-位或7-位卤素、C1-4烷基、C1-4烷氧基、苄氧基、酰胺基；R2为含氮的五元或六元取代杂环。该化合物可用于制备抗心律失常药物，制备方法反应条件温和，原料丰富且易得，操作和后处理简单。
• US7772230B2
  申请人：——

  公开号：US7772230B2

  公开（公告）日：2010-08-10