ethyl (1R,2S,10S,13S,14R,17S)-17-acetyloxy-7,10,14-trimethyl-8-azapentacyclo[11.8.0.02,10.04,9.014,19]henicosa-4,6,8,19-tetraene-6-carboxylate | 1552306-33-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ethyl (1R,2S,10S,13S,14R,17S)-17-acetyloxy-7,10,14-trimethyl-8-azapentacyclo[11.8.0.02,10.04,9.014,19]henicosa-4,6,8,19-tetraene-6-carboxylate
• CAS: 1552306-33-8
• 化学式: C₂₈H₃₇NO₄
• 分子量: 451.606
• InChiKey: RMWNJEUUSFSEEM-JPPQPORYSA-N

反应信息

• 作为产物：
  描述：

  3-acetoxy-16-aldehyde-17-aminoandrosta-5,16-diene 、 乙酰乙酸乙酯 在 碘 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 3.0h， 以65.2%的产率得到ethyl (1R,2S,10S,13S,14R,17S)-17-acetyloxy-7,10,14-trimethyl-8-azapentacyclo[11.8.0.02,10.04,9.014,19]henicosa-4,6,8,19-tetraene-6-carboxylate
  参考文献：
  名称：

  Synthesis and biological evaluation of dehydroepiandrosterone-fused thiazole, imidazo[2,1-b]thiazole, pyridine steroidal analogues

  摘要：

  A series of steroidal[17,16-b]thiazole, steroidal[1,2-b]pyridine and steroidal[17,16-d]thiazole[2,1-b]imidazo products were synthesized through a convenient and productive method. Anti-proliferation activity against EC109 (human esophageal carcinoma), EC9706 (human esophageal carcinoma) and MGC-803 (human gastric carcinoma) cell lines was examined in vitro. Among the screened compounds, several highly potential compounds were located. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2013.12.003